Prognostic significance of matrix metalloproteinase-20 overexpression in laryngeal squamous cell carcinoma

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Conclusion: Matrix metalloproteinase (MMP)-20 is overexpressed in laryngeal squamous cell carcinoma (LSCC) compared with the adjacent normal laryngeal epithelium and MMP-20 plays a role in lymph node metastasis. Overexpression of MMP-20 may be used as a significant prognostic factor for lymph node metastasis. All the findings indicate that MMP-20 may play a role in the initiation and progression of LSCC. Objective: The MMPs are a gene family of zinc-dependent endopeptidases that have been implicated in tumor invasion and metastasis, and MMP-20 is a new member of the MMP family. The purpose of this study was to investigate whether MMP-20 is overexpressed in human LSCC and, if so, the significance of its overexpression in relation to clinical parameters. Methods: We analyzed 33 cases of LSCC with RT-PCR and 73 cases of LSCC with immunohistochemistry compared with normal laryngeal epithelium. Results: We found that MMP-20 is overexpresssed in LSCC compared with the adjacent normal laryngeal epithelium.

Li, Yifan (author)
Liu, Zhongmin (author)
Zhang, Liyong (author)
Anniko, MattiUppsala universitet,Öron-, näs- och halssjukdomar(Swepub:uu)mattanni (author)
Duan, MaoliKarolinska Institutet (author)
Uppsala universitetÖron-, näs- och halssjukdomar (creator_code:org_t)

In:Acta Oto-Laryngologica: Informa UK Limited131:7, s. 769-7730001-64891651-2251

By the author/editor: Liu, Yehai; Li, Yifan; Liu, Zhongmin; Zhang, Liyong; Anniko, Matti; Duan, Maoli

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