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GPR162 is expressed...
GPR162 is expressed in the hypothalamus and is involved in food intake related behaviour
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- Sreedharan, Smitha (författare)
- Uppsala universitet,Funktionell farmakologi
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- Carlini, Valeria P (författare)
- Departamento de Farmacología, Universidad Nacional de Córdoba, Argentina
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- Jacobsson, Josefin A (författare)
- Uppsala universitet,Funktionell farmakologi
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visa fler...
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- Olszewski, Pawel K (författare)
- Uppsala universitet,Funktionell farmakologi
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- Haitina, Tatjana (författare)
- Uppsala universitet,Evolution och utvecklingsbiologi
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- Hammer, Joanna (författare)
- Uppsala universitet,Genomik
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- Stephansson, Olga (författare)
- Uppsala universitet,Funktionell farmakologi
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- Crona, Filip (författare)
- Uppsala universitet,Funktionell farmakologi
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- Sommer, Wolfgang H (författare)
- Department of Psychopharmacology, Central institute of Mental Health, Mannheim, Germany
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- Riserus, Ulf (författare)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Levine, Allen S (författare)
- Department of Food Science and Nutrition, Minnesota Obesity Center
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- Lannfelt, Lars (författare)
- Uppsala universitet,Geriatrik
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- Marcus, Claude (författare)
- Department for Clinical Science, Intervention and Technology, Karolinska Institute
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- Heilig, Marcus (författare)
- Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
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- de Barioglio, Susan R (författare)
- Departamento de Farmacología, Universidad Nacional de Córdoba, Argentina
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- Fredriksson, Robert (författare)
- Uppsala universitet,Funktionell farmakologi
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- Schiöth, Helgi (författare)
- Uppsala universitet,Funktionell farmakologi
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visa färre...
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(creator_code:org_t)
- 2011
- Engelska.
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- The Rhodopsin family of G protein-coupled receptors (GPCRs) includes about 270 non-olfactory receptors and is the largest family of GPCRs. About sixty non-olfactory Rhodopsin GPCRs are still orphans without known ligands, and fairly little is known about their functions. In this study, we present molecular, neuroanatomical, genetic and behavioral data implicating a Rhodopsin family protein, GPR162, in the regulation of food intake-related behaviour and glucose homeostasis. The real-time PCR data show that GPR162 is predominantly expressed in the CNS. The in situ hybridization results confirmed significant expression of GPR162 in several hypothalamic sites, amygdala, substantia nigra and ventral tegmental area, among others regions. In line with the distribution of the GPR162 mRNA in the feeding circuitry, antisense oligo knockdown of GPR162 caused a significant reduction in food intake but no effect was observed towards reduction in body weight in rats. Our human genetics studies suggest that genetic variants of GPR162 affect glucose homeostasis. In conclusion, this study provides evidence linking the orphan GPR162 gene with the regulation of food intake-related behaviour.
Publikations- och innehållstyp
- vet (ämneskategori)
- ovr (ämneskategori)
- Av författaren/redakt...
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Sreedharan, Smit ...
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Carlini, Valeria ...
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Jacobsson, Josef ...
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Olszewski, Pawel ...
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Haitina, Tatjana
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Hammer, Joanna
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visa fler...
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Stephansson, Olg ...
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Crona, Filip
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Sommer, Wolfgang ...
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Riserus, Ulf
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Levine, Allen S
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Lannfelt, Lars
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Marcus, Claude
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Heilig, Marcus
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de Barioglio, Su ...
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Fredriksson, Rob ...
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Schiöth, Helgi
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visa färre...
- Av lärosätet
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Uppsala universitet