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  • Aleman, SooKarolinska Institutet,Departments of Gastroenterology and Hepatology, Karolinska University Hospital/Karolinska Institutet, Stockholm (författare)

Health check-ups and family screening allow detection of hereditary hemochromatosis with less advanced liver fibrosis and survival comparable with the general population

  • Artikel/kapitelEngelska2011

Förlag, utgivningsår, omfång ...

  • 2011-06-15
  • Informa UK Limited,2011
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-158154
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-158154URI
  • https://doi.org/10.3109/00365521.2011.591426DOI
  • https://lup.lub.lu.se/record/2162283URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:123057217URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-70214URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Objective. The information concerning the morbidity and mortality of hereditary hemochromatosis is based primarily on clinical cohorts of symptomatic patients. The major aim of this study was to analyze the long-term prognosis for Swedish patients with this condition, with respect to both clinical features and survival, in relation to the route by which the disease was detected. Patients and methods. 373 patients with hemochromatosis detected through routine health checkups (n = 153), family screening (n = 44), symptoms of arthralgia (n = 23), investigation of other diseases/symptoms (n = 108) or signs of liver disease (n = 45) were monitored for a mean period of 11.9 +/- 5.8 years. The degree of liver fibrosis and survival were analyzed. Results. Overall survival among these patients was not significantly different from that of a matched normal population. The patients diagnosed through health check-ups and family screening were detected at an earlier age and had the highest rate of survival. Liver biopsy at the time of diagnosis revealed cirrhosis in 9% of those detected through the health check-ups and 5% in the case of family screening, compared with 13% for the group with arthralgia, 17% for other diseases/symptoms and 42% for liver disease. Conclusion. Health check-ups and family screening allow detection of hereditary hemochromatosis at an earlier age and with less advanced liver fibrosis, although a few of these patients have already developed cirrhosis. Our study indicates that iron indices should be included in health check-ups, and if abnormal, should lead to further investigation.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Endalib, SanamDepartments of Gastroenterology and Hepatology, Karolinska University Hospital/Karolinska Institutet, Stockholm (författare)
  • Stål, PerKarolinska Institutet,Departments of Gastroenterology and Hepatology, Karolinska University Hospital/Karolinska Institutet, Stockholm (författare)
  • Lööf, LarsUppsala universitet,Centrum för klinisk forskning, Västerås,Clinincal Research Centre, Västerås(Swepub:uu)larsloof (författare)
  • Lindgren, StefanLund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital, Lund/Malmö(Swepub:lu)medf-sli (författare)
  • Sandberg-Gertzen, HannaÖrebro University Hospital, Örebro (författare)
  • Almer, SvenÖstergötlands Läns Landsting,Linköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US(Swepub:liu)sveal38 (författare)
  • Olsson, SigvardSahlgrenska University Hospital, Göteborg (författare)
  • Danielsson, ÅkeUmeå University Hospital, Umeå (författare)
  • Wallerstedt, SvenSahlgrenska University Hospital, Göteborg (författare)
  • Hultcrantz, RolfKarolinska Institutet,Departments of Gastroenterology and Hepatology, Karolinska University Hospital/Karolinska Institutet, Stockholm (författare)
  • Karolinska InstitutetDepartments of Gastroenterology and Hepatology, Karolinska University Hospital/Karolinska Institutet, Stockholm (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Scandinavian Journal of Gastroenterology: Informa UK Limited46:9, s. 1118-11260036-55211502-7708

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