id:"swepub:oai:DiVA.org:uu-15909"
Sökning: id:"swepub:oai:DiVA.org:uu-15909" > Behavioural superse...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
- Archer, Trevor,1949Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology (författare)
Behavioural supersensitivity following neonatal 6-hydroxydopamine : Attenuation by MK-801
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
- 2007
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:uu-15909
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-15909URI
- https://doi.org/10.1007/BF03033920DOI
- https://gup.ub.gu.se/publication/91309URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- Male rat pups were administered 6-hydroxydopamine (6-OHDA, 75 μg, intracisternally, 30 min after desipramine, 25 mg/kg, s.c.) on Days 1 or 2 after birth, or were sham-operated (receiving vehicle). In four experiments, the acute effects of apomorphine, with or without pretreatment with MK-801 (0.03 mg/kg), upon motor activity in test chambers was measured. Acute treatment with apomorphine (0.1 mg/kg) increased locomotor, rearing and total activity markedly compared to both the acute saline administered 6-OHDA rats and the sham-operated rats administered saline. Acute MK-801 (0.03 mg/kg) co-administered shortly before (5 min) apomorphine (0.3 or 1.0 mg/kg) reduced markedly locomotion and total activity in 6-OHDA-treated and sham-operated rats. Rearing behaviour was increased in both the 6-OHDA groups of rats. Acute MK-801 increased activity in the 6-OHDA-treated rats, which was not observed in sham-operated rats. At the 0.3 and 1.0 mg/kg doses of apomorphine, neonatal 6-OHDA treament increased all three parameters of motor activity. Acute treatment with apomorphine (0.1 mg/kg) induced different effects on the motor activity of 6-OHDA-treated and sham-operated mice. In sham-operated rats apomorphine reduced motor activity during the 1st 30-min period but increased locomotion and total activity, but not rearing, during the 2nd and 3rd periods, whereas in 6-OHDA-treated rats, apomorphine increased locomotor, rearing and total activity markedly. Dopamine loss and serotonin elevation in the striatum and olfactory tubercle were confirmed. The present findings confirm the influence of non-competitive glutamate antagonists in attenuating the behavioural supersensitivity to dopamine antagonists.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- 6-Hydroxydopamine
- MK-801
- Neonatal
- Apomorphine
- Locomotion
- Rearing
- Total activity
- Supersensitivity
- Attenuation
- MEDICINE
- MEDICIN
- monoamine-depleted mice
- dopamine-receptor supersensitivity
- induced oral activity
- nmda antagonist
- antiparkinsonian efficacy
- locomotor stimulation
- parkinsons-disease
- developing rats
- brain dopamine
- motor-activity
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Fredriksson, AndersGothenburg University,Göteborgs universitet,Uppsala universitet,Institutionen för neurovetenskap,Psykologiska institutionen,Department of Psychology(Swepub:uu)andefred (författare)
- Göteborgs universitetPsykologiska institutionen (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Neurotoxicity research12:2, s. 113-1241029-84281476-3524
Internetlänk
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Archer, Trevor, ...
- Fredriksson, And ...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Medicinska och f ...
- och Neurovetenskaper
- Artiklar i publikationen
- Neurotoxicity re ...
- Av lärosätet
- Uppsala universitet
- Göteborgs universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
