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Is there a role for...
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Hadzidimitriou, Anastasia
(author)
Is there a role for antigen selection in mantle cell lymphoma? : Immunogenetic support from a series of 807 cases
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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American Society of Hematology,2011
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-159465
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-159465URI
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https://doi.org/10.1182/blood-2011-03-343434DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:123225680URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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We examined 807 productive IGHV-IGHD-IGHJ gene rearrangements from mantle cell lymphoma (MCL) cases, by far the largest series to date. The IGHV gene repertoire was remarkably biased, with IGHV3-21, IGHV4-34, IGHV1-8, and IGHV3-23 accounting for 46.3% of the cohort. Eighty-four of 807 (10.4%) cases, mainly using the IGHV3-21 and IGHV4-34 genes, were found to bear stereotyped heavy complementarity-determining region 3 (VH CDR3) sequences and were placed in 38 clusters. Notably, the MCL stereotypes were distinct from those reported for chronic lymphocytic leukemia. Based on somatic hypermutation (SHM) status, 238/807 sequences (29.5%) carried IGHV genes with 100% germ line identity; the remainder (569/807; 70.5%) exhibited different SHM impact, ranging from minimal (in most cases) to pronounced. Shared replacement mutations across the IGHV gene were identified for certain subgroups, especially those using IGHV3-21, IGHV1-8, and IGHV3-23. Comparison with other entities, in particular CLL, revealed that several of these mutations were "MCL-biased." In conclusion, MCL is characterized by a highly restricted immunoglobulin gene repertoire with stereotyped VH CDR3s and very precise SHM targeting, strongly implying a role for antigen-driven selection of the clonogenic progenitors. Hence, an antigen-driven origin of MCL could be envisaged, at least for subsets of cases.
Added entries (persons, corporate bodies, meetings, titles ...)
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Agathangelidis, Andreas
(author)
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Darzentas, Nikos
(author)
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Murray, FionaUppsala universitet,Institutionen för immunologi, genetik och patologi(Swepub:uu)fimur450
(author)
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Delfau-Larue, Marie-Helene
(author)
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Pedersen, Lone Bredo
(author)
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Navarro Lopez, Alba
(author)
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Dagklis, Antonis
(author)
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Rombout, Paul
(author)
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Beldjord, Kheira
(author)
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Kolstad, Arne
(author)
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Dreyling, Martin H.
(author)
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Anagnostopoulos, Achilles
(author)
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Tsaftaris, Athanasios
(author)
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Mavragani-Tsipidou, Penelope
(author)
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Rosenwald, Andreas
(author)
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Ponzoni, Maurilio
(author)
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Groenen, Patricia
(author)
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Ghia, Paolo
(author)
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Sander, BirgittaKarolinska Institutet
(author)
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Papadaki, Theodora
(author)
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Campo, Elias
(author)
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Geisler, Christian
(author)
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Rosenquist, RichardUppsala universitet,Institutionen för immunologi, genetik och patologi(Swepub:uu)richrose
(author)
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Davi, Frederic
(author)
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Pott, Christiane
(author)
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Stamatopoulos, Kostas
(author)
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Uppsala universitetInstitutionen för immunologi, genetik och patologi
(creator_code:org_t)
Related titles
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In:Blood: American Society of Hematology118:11, s. 3088-30950006-49711528-0020
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Navarro Lopez, A ...
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