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Sökning: id:"swepub:oai:DiVA.org:uu-15959" > Development of abdo...

  • Branth, StefanUppsala universitet,Institutionen för medicinska vetenskaper (författare)

Development of abdominal fat and incipient metabolic syndrome in young healthy men exposed to long-term stress

  • Artikel/kapitelEngelska2007

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2007
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-15959
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-15959URI
  • https://doi.org/10.1016/j.numecd.2006.03.001DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:115974723URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND AND AIM: The sympathetic nervous system may be involved in the pathophysiology of insulin resistance and metabolic cardiovascular syndrome in young men. The aim was to study the effects of long-term stress on different features of the metabolic syndrome (MES) in formerly non-obese healthy young males during 5 months of defined conditions. METHODS AND RESULTS: Sixteen healthy male sailors (mean age 36.5 (SD)+/-7 years) participating in a sailing race around the world were recruited for the study. Investigations were done before the start and at stop overs after finishing laps 1, 2 and 4 (1, 2(1/2) and 5 months, respectively). Anthropometric and blood pressure data as well as biochemical data associated with MES were substantiated. Food intake and exercise were chartered and largely controlled. A mean weight loss of 4.5+/-2 kg (P<0.005), comprising both fat and lean body mass, was recorded during the first lap. Subsequently after 5 months, a weight gain, mainly consisting of 1.2+/-1.1 kg body fat (P<0.05), took place, concomitantly with a protein mass drop of 0.6+/-1.1 kg (P<0.05). The body fat gain accumulated on the abdominal region. Elevated blood levels of HbA1c, insulin and the triglycerides/high-density lipoprotein ratio were also observed during the race. Likewise heart rate and systolic blood pressure increased slightly but to a statistically significant extent. CONCLUSIONS: Non-obese healthy young men exposed to long-term stress developed abdominal obesity and signs of a metabolic syndrome in embryo, also emphasized by biochemical and blood pressure alterations. It is suggested that long-term and sustained stress activation might be an additional risk factor for the development of MES, even after control of dietary and exercise habits.

Ämnesord och genrebeteckningar

  • MEDICINE
  • MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ronquist, GunnarUppsala universitet,Klinisk kemi(Swepub:uu)guron517 (författare)
  • Stridsberg, MatsUppsala universitet,Klinisk kemi(Swepub:uu)matsstri (författare)
  • Hambraeus, LeifUppsala universitet,Institutionen för medicinska vetenskaper (författare)
  • Kindgren, ErikUppsala universitet,Institutionen för medicinska vetenskaper (författare)
  • Olsson, RogerUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)rogeolss (författare)
  • Carlander, DavidUppsala universitet,Klinisk kemi,Biologisk struktur och funktion (författare)
  • Arnetz, BengtUppsala universitet,Socialmedicin(Swepub:uu)bengarne (författare)
  • Uppsala universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:NMCD. Nutrition Metabolism and Cardiovascular Diseases: Elsevier BV17:6, s. 427-4350939-47531590-3729

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