Increased neurokinin-1 receptor availability in temporal lobe epilepsy: A positron emission tomography study using [(11)C]GR205171

Danfors, TorstenUppsala universitet,Neurologi,Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden; Section of Nuclear Medicine and PET, Department of Radiology, Oncology and Radiation Sciences, Uppsala University, Sweden (författare)

Increased neurokinin-1 receptor availability in temporal lobe epilepsy : A positron emission tomography study using [(11)C]GR205171

PURPOSE: Activation of the neurokinin-1 (NK1) receptor by neuropeptide substance P (SP) induces and maintains epileptic activity in various experimental models of epilepsy. The primary objective of this study was to investigate whether neurobiological changes linked to NK1-SP receptor system are associated with hyperexcitability in patients with temporal lobe epilepsy (TLE). A secondary objective was to investigate the relationship between seizure frequency and NK1 receptor availability. METHODS: A positron emission tomography study was conducted with the selective NK1 receptor antagonist [(11)C]GR205171 in nine patients with TLE and 18 healthy control participants. Parametric PET images were generated using the Patlak graphical method, with cerebellum as reference region. Data analyses including group comparisons were performed using statistical parametric mapping. RESULTS: Patients with TLE showed increased NK1 receptor availability in both hemispheres with the most pronounced increase in anterior cingulate gyrus ipsilateral to seizure onset. A positive correlation between NK1 receptor availability and seizure frequency was observed in the medial temporal lobe and in the lentiform nucleus ipsilateral to the seizure onset. CONCLUSION: Our results suggest that there is an intrinsic network using the NK1-SP receptor system for synaptic transmission and epileptiform activity in TLE.

Åhs, FredrikUppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden(Swepub:miun)freahs (författare)
Appel, LieuweUppsala universitet,Enheten för nuklearmedicin och PET,Section of Nuclear Medicine and PET, Department of Radiology, Oncology and Radiation Sciences, Uppsala University, Sweden(Swepub:uu)lap02157 (författare)
Linnman, ClasUppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden; P.A.I.N. group, McLean Hospital, Harvard Medical School, Boston, MA, USA(Swepub:uu)cllin103 (författare)
Fredrikson, MatsUppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden(Swepub:uu)matsfred (författare)
Furmark, TomasUppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden(Swepub:uu)tomafurm (författare)
Kumlien, EvaUppsala universitet,Neurologi,Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden(Swepub:uu)evakumli (författare)
Uppsala universitetNeurologi (creator_code:org_t)

Av författaren/redakt...: Danfors, Torsten; Åhs, Fredrik; Appel, Lieuwe; Linnman, Clas; Fredrikson, Mats; Furmark, Tomas; visa fler...; Kumlien, Eva; visa färre...

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