SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Smedh Kennet)
 

Search: WFRF:(Smedh Kennet) > (2005-2009) > Leukocyte scintigra...

  • Almer, Sven,1953-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Gastroenterologi och hepatologi,Endokrin- och magtarmmedicinska kliniken US (author)

Leukocyte scintigraphy compared to intraoperative small bowel enteroscopy and laparotomy findings in Crohn's disease

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • Oxford University Press (OUP),2007
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-16031
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-16031URI
  • https://doi.org/10.1002/ibd.20001DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-37454URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Leukocyte scintigraphy is a noninvasive investigation to assess inflammation. We evaluated the utility of labeled leukocytes to detect small bowel inflammation and disease complications in Crohn's disease and compared it to whole small bowel enteroscopy and laparotomy findings.Methods: Scintigraphy with technetium-99m exametazime-labeled leukocytes was prospectively performed in 48 patients with Crohn's disease a few days before laparotomy; 41 also had an intraoperative small bowel enteroscopy. The same procedures were performed in 8 control patients. Independent grading of scans was compared with the results of enteroscopy and with surgical, histopathologic, and clinical data.Results: In the 8 control patients leukocyte scan, endoscopy, and histopathology were all negative for the small bowel. In patients with Crohn's disease and small bowel inflammation seen at enteroscopy and/or laparotomy (n = 39) the scan was positive in 33. In 8 patients without macroscopic small bowel inflammation, the scan was positive for the small bowel in 3 patients; at histology, 2 of 3 had inflammation. When combining results for patients and controls, the sensitivity of leukocyte scan for macroscopically evident small bowel inflammation was 0.85, specificity 0.81, accuracy 0.84, positive predictive value 0.92, and negative predictive value 0.68. Scintigraphy detected inflammatory lesions not known before laparotomy in 16 of 47 (34%) Crohn's disease patients and showed uptake in 25 of 35 (71%) bowel strictures. It was diagnostic regarding 4 of 8 abscesses and 9 of 15 fistulas. In 6 patients (13%) lesions first demonstrated by leukocyte scintigraphy were treated during the surgery performed.Conclusions: Leukocyte scintigraphy reliably detects small bowel inflammation in Crohn's disease. It gives additional information on the presence of inflammatory lesions in a fraction of patients planned for surgery.

Subject headings and genre

  • Adolescent
  • Adult
  • Aged
  • Crohn Disease/*diagnosis/radionuclide imaging/surgery
  • Endoscopy; Gastrointestinal
  • Female
  • Humans
  • Ileum/pathology/radionuclide imaging
  • Intestine; Small
  • Intraoperative Period
  • Jejunum/pathology/radionuclide imaging
  • Laparotomy
  • Leukocytes
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Radiopharmaceuticals/*diagnostic use
  • Sensitivity and Specificity
  • Technetium Tc 99m Exametazime/*diagnostic use
  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Granerus, Göran,1939-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Klinisk fysiologi,Fysiologiska kliniken(Swepub:liu)gorgr70 (author)
  • Ström, Magnus,1945-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Gastroenterologi och hepatologi,Endokrin- och magtarmmedicinska kliniken US(Swepub:liu)magst47 (author)
  • Olaison, Gunnar (author)
  • Bonnet, Joëlle (author)
  • Lémann, Marc (author)
  • Smedh, KennetUppsala universitet,Centrum för klinisk forskning, Västerås(Swepub:uu)kensm722 (author)
  • Franzén, Lennart (author)
  • Bertheau, Philippe (author)
  • Cattan, Pierre (author)
  • Rain, Jean-Didier (author)
  • Modigliani, Robert (author)
  • Linköpings universitetHälsouniversitetet (creator_code:org_t)

Related titles

  • In:Inflammatory Bowel Diseases: Oxford University Press (OUP)13:2, s. 164-1741078-09981536-4844

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view