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Leukocyte scintigra...
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Almer, Sven,1953-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Gastroenterologi och hepatologi,Endokrin- och magtarmmedicinska kliniken US
(författare)
Leukocyte scintigraphy compared to intraoperative small bowel enteroscopy and laparotomy findings in Crohn's disease
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
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Oxford University Press (OUP),2007
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-16031
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-16031URI
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https://doi.org/10.1002/ibd.20001DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-37454URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: Leukocyte scintigraphy is a noninvasive investigation to assess inflammation. We evaluated the utility of labeled leukocytes to detect small bowel inflammation and disease complications in Crohn's disease and compared it to whole small bowel enteroscopy and laparotomy findings.Methods: Scintigraphy with technetium-99m exametazime-labeled leukocytes was prospectively performed in 48 patients with Crohn's disease a few days before laparotomy; 41 also had an intraoperative small bowel enteroscopy. The same procedures were performed in 8 control patients. Independent grading of scans was compared with the results of enteroscopy and with surgical, histopathologic, and clinical data.Results: In the 8 control patients leukocyte scan, endoscopy, and histopathology were all negative for the small bowel. In patients with Crohn's disease and small bowel inflammation seen at enteroscopy and/or laparotomy (n = 39) the scan was positive in 33. In 8 patients without macroscopic small bowel inflammation, the scan was positive for the small bowel in 3 patients; at histology, 2 of 3 had inflammation. When combining results for patients and controls, the sensitivity of leukocyte scan for macroscopically evident small bowel inflammation was 0.85, specificity 0.81, accuracy 0.84, positive predictive value 0.92, and negative predictive value 0.68. Scintigraphy detected inflammatory lesions not known before laparotomy in 16 of 47 (34%) Crohn's disease patients and showed uptake in 25 of 35 (71%) bowel strictures. It was diagnostic regarding 4 of 8 abscesses and 9 of 15 fistulas. In 6 patients (13%) lesions first demonstrated by leukocyte scintigraphy were treated during the surgery performed.Conclusions: Leukocyte scintigraphy reliably detects small bowel inflammation in Crohn's disease. It gives additional information on the presence of inflammatory lesions in a fraction of patients planned for surgery.
Ämnesord och genrebeteckningar
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Adolescent
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Adult
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Aged
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Crohn Disease/*diagnosis/radionuclide imaging/surgery
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Endoscopy; Gastrointestinal
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Female
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Humans
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Ileum/pathology/radionuclide imaging
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Intestine; Small
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Intraoperative Period
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Jejunum/pathology/radionuclide imaging
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Laparotomy
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Leukocytes
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Male
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Middle Aged
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Predictive Value of Tests
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Radiopharmaceuticals/*diagnostic use
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Sensitivity and Specificity
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Technetium Tc 99m Exametazime/*diagnostic use
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Granerus, Göran,1939-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Klinisk fysiologi,Fysiologiska kliniken(Swepub:liu)gorgr70
(författare)
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Ström, Magnus,1945-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Gastroenterologi och hepatologi,Endokrin- och magtarmmedicinska kliniken US(Swepub:liu)magst47
(författare)
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Olaison, Gunnar
(författare)
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Bonnet, Joëlle
(författare)
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Lémann, Marc
(författare)
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Smedh, KennetUppsala universitet,Centrum för klinisk forskning, Västerås(Swepub:uu)kensm722
(författare)
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Franzén, Lennart
(författare)
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Bertheau, Philippe
(författare)
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Cattan, Pierre
(författare)
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Rain, Jean-Didier
(författare)
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Modigliani, Robert
(författare)
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Linköpings universitetHälsouniversitetet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Inflammatory Bowel Diseases: Oxford University Press (OUP)13:2, s. 164-1741078-09981536-4844
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Almer, Sven, 195 ...
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Granerus, Göran, ...
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Ström, Magnus, 1 ...
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Olaison, Gunnar
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Bonnet, Joëlle
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Lémann, Marc
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visa fler...
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Smedh, Kennet
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Franzén, Lennart
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Bertheau, Philip ...
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Cattan, Pierre
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Rain, Jean-Didie ...
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Modigliani, Robe ...
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visa färre...
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Inflammatory Bow ...
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Uppsala universitet
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Linköpings universitet