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Sökning: onr:"swepub:oai:DiVA.org:uu-16057" > Increase in the rel...

  • Ingelsson, MartinUppsala universitet,Geriatrik,Geriatrics (författare)

Increase in the relative expression of tau with four microtubule binding repeat regions in frontotemporal lobar degeneration and progressive supranuclear palsy brains

  • Artikel/kapitelEngelska2007

Förlag, utgivningsår, omfång ...

  • 2007-08-25
  • Springer Science and Business Media LLC,2007
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-16057
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-16057URI
  • https://doi.org/10.1007/s00401-007-0280-zDOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Some cases of familial frontotemporal dementia (FTD) leading to frontotemporal lobar degeneration (FTLD) are caused by mutations in tau on chromosome 17 (FTDP-17). Certain mutations alter the ratio between four (4R tau) and three (3R tau) repeat tau isoforms whereas cases with progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) mainly have 4R tau brain pathology. We assessed tau mRNA and protein levels in frontal cortex from 15 sporadic FTLD, 21 PSP, 5 CBD, 15 Alzheimer’s disease (AD) and 16 control brains. Moreover, we investigated the disease association and possible tau splicing effects of the tau H1 haplotype. Cases with FTLD and PSP had lower tau mRNA levels than control brains. When analyzing 4R tau and 3R tau mRNA separately, control subjects displayed a 4R tau/3R tau ratio of 0.48. Surprisingly, FTLD brains displayed a more elevated ratio (1.32) than PSP brains (1.12). Also, several FTLD and PSP cases had higher 4R tau/3R tau mRNA than FTDP-17 cases, included as reference tissues, and the ratio increase was seen regardless of underlying histopathology, i.e. both for tau-positive and tau-negative FTLD cases. Furthermore, total tau protein levels were slightly decreased in both FTLD and AD as compared to control subjects. Finally, we confirmed the association of tau H1 with PSP, but could not find any haplotype-related effect on tau exon 10 splicing. In conclusion, we demonstrated increased but largely variable 4R tau/3R tau mRNA ratios in FTLD and PSP cases, suggesting heterogeneous pathophysiological processes within these disorders.

Ämnesord och genrebeteckningar

  • Aged
  • Aged; 80 and over
  • Alternative Splicing/genetics
  • Brain/*metabolism/pathology/physiopathology
  • DNA Mutational Analysis
  • Dementia/*genetics/metabolism/pathology/physiopathology
  • Female
  • Genetic Predisposition to Disease/*genetics
  • Genetic Screening
  • Haplotypes/genetics
  • Humans
  • Male
  • Middle Aged
  • Mutation/*genetics
  • Protein Isoforms/genetics
  • RNA; Messenger/metabolism
  • Supranuclear Palsy; Progressive/*genetics/metabolism/pathology/physiopathology
  • Trinucleotide Repeats/genetics
  • Up-Regulation/genetics
  • tau Proteins/chemistry/*genetics/metabolism
  • MEDICINE
  • MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ramasamy, Karunya (författare)
  • Russ, Carsten (författare)
  • Freeman, Stefanie H (författare)
  • Orne, Jennifer (författare)
  • Raju, Susan (författare)
  • Matsui, Toshifumi (författare)
  • Growdon, John H (författare)
  • Frosch, Matthew P (författare)
  • Ghetti, Bernardino (författare)
  • Brown, Robert H (författare)
  • Irizarry, Michael C (författare)
  • Hyman, Bradley T (författare)
  • Uppsala universitetGeriatrik (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Acta Neuropathologica: Springer Science and Business Media LLC114:5, s. 471-4790001-63221432-0533

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