MR spectroscopy of the human prostate using surface coil at 3 T: Metabolite ratios, age-dependent effects, and diagnostic possibilities

MR spectroscopy of the human prostate using surface coil at 3 T : Metabolite ratios, age-dependent effects, and diagnostic possibilities

PURPOSE: To measure prostate spectra of healthy volunteers using a surface coil, to demonstrate age-dependent effects, and to investigate diagnostic possibilities for prostate cancer detection. MATERIALS AND METHODS: Single-voxel and 2D magnetic resonance spectroscopic imaging (MRSI) spectra of 51 healthy volunteers with biopsy-proven prostate carcinoma of 20 patients for comparison were measured and processed using the LCModel. The mean normalized spectra and mean metabolite-to-citrate intensity ratios were computed. RESULTS: Metabolite-to-citrate ratios of healthy volunteers were lower in the older group (>51 years) than in the younger group (<45 years). The peripheral zone (PZ) revealed a lower metabolite-to-citrate intensity ratio than the central gland (CG). Age-related differences in metabolite-to-citrate ratio were insignificant in the voxels with predominantly CG tissue, whereas significant differences were found in the PZ. Sensitivity in detecting prostate cancer by single-voxel spectroscopy (SVS) and 2D MRSI was 75% and 80%, respectively. CONCLUSION: SVS and 2D MRSI of the prostate at 3 T, using a surface coil, are useful in situations when insertion of the endorectal coil into the rectum is difficult or impossible. Our findings of age-dependent effects may be of importance for the analysis of patient spectra.

Jorulf, HåkanUppsala universitet,Enheten för radiologi(Swepub:uu)hajor451 (författare)
Bergman, AntoninaUppsala universitet,Enheten för radiologi(Swepub:uu)abe03125 (författare)
Ortiz-Nieto, FranciscoUppsala universitet,Enheten för radiologi(Swepub:uu)fraor613 (författare)
Häggman, MichaelUppsala universitet,Urologkirurgi(Swepub:uu)michhagg (författare)
Ahlström, HåkanUppsala universitet,Enheten för radiologi(Swepub:uu)hakanahl (författare)
Uppsala universitetEnheten för radiologi (creator_code:org_t)

Ingår i:Journal of Magnetic Resonance Imaging: Wiley34:6, s. 1277-12841053-18071522-2586

Av författaren/redakt...: Weis, Jan; Jorulf, Håkan; Bergman, Antonin ...; Ortiz-Nieto, Fra ...; Häggman, Michael; Ahlström, Håkan

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.