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The therapeutic rol...
The therapeutic role of endothelial progenitor cells in Type 1 diabetes mellitus
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- Grapensparr, Liza (författare)
- Uppsala universitet,Integrativ Fysiologi
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- Olerud, Johan (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Klinisk immunologi
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- Vasylovska, Svitlana (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Neuroanatomi
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- Carlsson, Per-Ola (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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(creator_code:org_t)
- 2011
- 2011
- Engelska.
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Ingår i: Regenerative Medicine. - 1746-0751 .- 1746-076X. ; 6:5, s. 599-605
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- Pancreatic beta-cells sense and adjust the blood glucose level by secretion of insulin. In Type 1 diabetes mellitus, these insulin-producing cells are destroyed, leaving the patients incapable of regulating blood glucose homeostasis. At the time of diagnosis, most patients still have 20-30% of their original beta-cell mass remaining. These residual beta-cells are targets for intervention therapies aimed at preventing further autoimmune destruction, in addition to increasing the number of existing beta-cells. Such a therapeutic option is highly desirable since it may lead to a full recovery of newly diagnosed patients, with no need for further treatment with immunosuppressant drugs or exogenous insulin administration. In this article, we propose that endothelial progenitor cells, a cell type known to promote and support neovascularization following endothelial injury, may be used as part of a combinational stem cell therapy aimed to improve the vascularization, survival and proliferation of beta-cells.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- beta-cells
- endothelial cells
- endothelial progenitor cells
- stem cells
- Type 1 diabetes
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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