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APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome
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- Fallaize, Rosalind (författare)
- Univ Reading, Hugh Sinclair Unit Human Nutr, Reading RG6 6AP, Berks, England.;Univ Reading, Inst Cardiovasc & Metab Res, Reading RG6 6AP, Berks, England.;Univ Hertfordshire, Sch Life & Med Sci, Coll Lane, Hatfield AL10 9AB, Herts, England.
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- Carvalho-Wells, Andrew L. (författare)
- Univ Reading, Hugh Sinclair Unit Human Nutr, Reading RG6 6AP, Berks, England.;Univ Reading, Inst Cardiovasc & Metab Res, Reading RG6 6AP, Berks, England.
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- Tierney, Audrey C. (författare)
- Univ Coll Dublin, Conway Inst, Nutrigen Res Grp, Dublin, Ireland.
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- Univ Reading, Hugh Sinclair Unit Human Nutr, Reading RG6 6AP, Berks, England;Univ Reading, Inst Cardiovasc & Metab Res, Reading RG6 6AP, Berks, England.;Univ Hertfordshire, Sch Life & Med Sci, Coll Lane, Hatfield AL10 9AB, Herts, England. Univ Reading, Hugh Sinclair Unit Human Nutr, Reading RG6 6AP, Berks, England.;Univ Reading, Inst Cardiovasc & Metab Res, Reading RG6 6AP, Berks, England. (creator_code:org_t)
- 2017-07-24
- 2017
- Engelska.
- Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Metabolic markers associated with the Metabolic Syndrome (MetS) may be affected by interactions between the APOE genotype and plasma fatty acids (FA). In this study, we explored FA-gene interactions between the missense APOE polymorphisms and FA status on metabolic markers in MetS. Plasma FA, blood pressure, insulin sensitivity and lipid concentrations were determined at baseline and following a 12-week randomized, controlled, parallel, dietary FA intervention in 442 adults with MetS (LIPGENE study). FA-APOE gene interactions at baseline and following change in plasma FA were assessed using adjusted general linear models. At baseline E4 carriers had higher plasma concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apo B) compared with E2 carriers; and higher TC, LDL-C and apo B compared with E3/E3. Whilst elevated plasma n-3 polyunsaturated FA (PUFA) was associated with a beneficially lower concentration of apo CIII in E2 carriers, a high proportion of plasma C16:0 was associated with insulin resistance in E4 carriers. Following FA intervention, a reduction in plasma long-chain n-3 PUFA was associated with a reduction in apo CII concentration in E2 carriers. Our novel data suggest that individuals with MetS may benefit from personalized dietary interventions based on APOE genotype.
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- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
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