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Paediatric B-cell precursor acute lymphoblastic leukaemia with t(1;19)(q23;p13) : clinical and cytogenetic characteristics of 47 cases from the Nordic countries treated according to NOPHO protocols
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Andersen, Mette K. (author)
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Autio, Kirsi (author)
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- Barbany, Gisela (author)
- Karolinska Institutet
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Borgstroem, Georg (author)
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- Cavelier, Lucia (author)
- Uppsala universitet,Medicinsk genetik
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- Golovleva, Irina (author)
- Umeå universitet,Institutionen för medicinsk biovetenskap
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Heim, Sverre (author)
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Heinonen, Kristina (author)
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Hovland, Randi (author)
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Johannsson, Johann H. (author)
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- Johansson, Bertil (author)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine
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Kjeldsen, Eigil (author)
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- Nordgren, Ann (author)
- Karolinska Institutet
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- Palmqvist, Lars, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
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- Forestier, Erik (author)
- Umeå universitet,Institutionen för medicinsk biovetenskap
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(creator_code:org_t)
- 2011-09-09
- 2011
- English.
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In: British Journal of Haematology. - Oxford : Wiley. - 0007-1048 .- 1365-2141. ; 155:2, s. 235-243
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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Abstract
Subject headings
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- The translocation t(1;19)(q23;p13)/der(19) t(1;19) is a risk stratifying aberration in childhood B-cell precursor acute lymphoblastic leukaemia (BCP ALL) in the Nordic countries. We have identified 47 children/adolescents with t(1;19)/der(19) t(1;19)-positive BCP ALL treated on two successive Nordic Society of Paediatric Haematology and Oncology (NOPHO) protocols between 1992 and 2007 and have reviewed the clinical and cytogenetic characteristics of these cases, comprising 1.8% of all cases. The translocation was balanced in 15 cases (32%) and unbalanced in 29 cases (62%). The most common additional chromosome abnormalities were del(9p), i(9q), del(6q), and del(13q). The median age was 7 years, the median white blood cell (WBC) count was 16 x 10(9)/l, and the female/male ratio was 1.2. The predicted event-free survival (EFS) at 5 and 10 years was 0.79, whereas the predicted overall survival (OS) at 5 and 10 years was 0.85 and 0.82, respectively. Nine patients had a bone marrow relapse after a median of 23 months; no patient had a central nervous system relapse. Additional cytogenetic abnormalities, age, gender, WBC count or whether the t(1;19) was balanced or unbalanced did not influence EFS or OS. Compared to cases with t(12,21) and high hyperdiploidy, EFS was similar, but overall survival was worse in patients with t(1;19)/der(19) t(1;19) (P = 0.004).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- acute lymphoblastic leukaemia
- paediatric
- t(1
- 19)
- TCF3
- PBX1
- acute lymphoblastic leukaemia; paediatric; t(1;19); TCF3; PBX1
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Andersen, Mette ...
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Autio, Kirsi
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Barbany, Gisela
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Borgstroem, Geor ...
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Cavelier, Lucia
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Golovleva, Irina
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show more...
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Heim, Sverre
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Heinonen, Kristi ...
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Hovland, Randi
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Johannsson, Joha ...
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Johansson, Berti ...
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Kjeldsen, Eigil
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Nordgren, Ann
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Palmqvist, Lars, ...
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Forestier, Erik
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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British Journal ...
- By the university
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Uppsala University
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Lund University
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University of Gothenburg
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Karolinska Institutet
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Umeå University