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- Lesch, ChristineStockholms universitet,Institutionen för molekylärbiologi och funktionsgenomik (author)
A role for Hemolectin in coagulation and immunity in Drosophila melanogaster
- Article/chapterEnglish2007
Publisher, publication year, extent ...
- Elsevier BV,2007
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-16265
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-16265URI
- https://doi.org/10.1016/j.dci.2007.03.012DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-14250URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-24443URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Hemolectin has been identified as a candidate clotting factor in Drosophila. We reassessed the domain structure of Hemolectin (Hml) and propose that instead of C-type lectin domains, the two discoidin domains are most likely responsible for the protein's lectin activity. We also tested Hml's role in coagulation and immunity in Drosophila. Here we describe the isolation of a new hml allele in a forward screen for coagulation mutants, and our characterization of this and two other hml alleles, one of which is a functional null. While loss of Hml had strong effects on larval hemolymph coagulation ex vivo, mutant larvae survived wounding. Drosophila thus possesses redundant hemostatic mechanisms. We also found that loss of Hml in immune-handicapped adults rendered them more sensitive to Gram(-) bacteria infection. This demonstrates an immunological role of this clotting protein and reinforces the importance of the clot in insect immunity.
Subject headings and genre
- NATURVETENSKAP Biologi hsv//swe
- NATURAL SCIENCES Biological Sciences hsv//eng
- NATURVETENSKAP Biologi Immunologi hsv//swe
- NATURAL SCIENCES Biological Sciences Immunology hsv//eng
- NATURVETENSKAP Biologi Zoologi hsv//swe
- NATURAL SCIENCES Biological Sciences Zoology hsv//eng
- NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
- insect immunity
- innate immunity
- hemolymph coagulation
- discoidin
- lectin
- Biology
- Biologi
- Molecular biology
Added entries (persons, corporate bodies, meetings, titles ...)
- Goto, AkiraUPR9022 du CNRS, IBMC, Strasbourg, France (author)
- Lindgren, MalinSödertörns högskola,Institutionen för livsvetenskaper(Swepub:sh)SHMNLN02 (author)
- Bidla, GawaStockholms universitet,Institutionen för molekylärbiologi och funktionsgenomik (author)
- Dushay, Mitchell S.Södertörns högskola,Uppsala universitet,Jämförande fysiologi,Institutionen för livsvetenskaper,Uppsala University(Swepub:sh)SHMHDY (author)
- Theopold, UlrichStockholms universitet,Institutionen för molekylärbiologi och funktionsgenomik(Swepub:su)utheo (author)
- Stockholms universitetInstitutionen för molekylärbiologi och funktionsgenomik (creator_code:org_t)
Related titles
- In:Developmental and Comparative Immunology: Elsevier BV31:12, s. 1255-12630145-305X1879-0089
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