id:"swepub:oai:DiVA.org:uu-16296"
Search: id:"swepub:oai:DiVA.org:uu-16296" > High diversity in f...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Haitina, TatjanaUppsala universitet,Farmakologi (author)
High diversity in functional properties of melanocortin 1 receptor (MC1R) in divergent primate species is more strongly associated with phylogeny than coat color
- Article/chapterEnglish2007
Publisher, publication year, extent ...
- 2007-05-23
- Oxford University Press (OUP),2007
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-16296
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-16296URI
- https://doi.org/10.1093/molbev/msm134DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- We have characterized the biochemical function of the melanocortin1 receptor (MC1R), a critical regulator of melanin synthesis,from 9 phylogenetically diverse primate species with varyingcoat colors. There is substantial diversity in melanocyte-stimulatinghormone (MSH) binding affinity and basal levels of activityin the cloned MC1Rs. MSH binding was lost independently in lemurand New World monkey lineages, whereas high basal levels ofMC1R activity occur in lemurs and some New World monkeys andOld World monkeys. Highest levels of basal activity were foundin the MC1R of ruffed lemurs, which have the E94K mutation thatleads to constitutive activation in other species. In 3 species(2 lemurs and the howler monkey), we report the novel findingthat binding and inhibition of MC1R by agouti signaling protein(ASIP) can occur when MSH binding has been lost, thus enablingcontinuing regulation of the melanin type via ASIP expression.Together, these findings can explain the previous paradox ofa predominantly pheomelanic coat in the red ruffed lemur (Vareciarubra). The presence of a functional, MSH-responsive MC1R inorangutan demonstrates that the mechanism of red hair generationin this ape is different from the prevalent mechanism in Europeanhuman populations. Overall, we have found unexpected diversityin MC1R function among primates and show that the evolutionof the regulatory control of MC1R activity occurs by independentvariation of 3 distinct mechanisms: basal MC1R activity, MSHbinding and activation, and ASIP binding and inhibition. Thisdiversity of function is broadly associated with primate phylogenyand does not have a simple relation to coat color phenotypewithin primate clades.
Subject headings and genre
- NATURVETENSKAP Biologi hsv//swe
- NATURAL SCIENCES Biological Sciences hsv//eng
- Amino acid sequence
- animals
- cell line
- cercopithecidae/genetics
- colobus/genetics
- cyclic AMP/metabolism
- evolution
- molecular
- hair color/*genetics
- humans
- Lemur/genetics
- Macaca/genetics
- melanocyte-stimulating hormones/metabolism
- molecular sequence data
- phylogeny
- platyrrhini/genetics
- Pongo pygmaeus/genetics
- primates/classification/*genetics
- radioligand assay
- receptor
- melanocortin
- Type 1/*genetics/metabolism
- sequence homology
- amino acid
- MSH
- primate
- coat color
- G protein-coupled receptor
- MC1
- MEDICINE
- MEDICIN
- Biology
- Biologi
Added entries (persons, corporate bodies, meetings, titles ...)
- Ringholm, AnetaUppsala universitet,Farmakologi (author)
- Kelly, Joanne (author)
- Mundy, Nicholas I (author)
- Schiöth, Helgi B.Uppsala universitet,Farmakologi (author)
- Uppsala universitetFarmakologi (creator_code:org_t)
Related titles
- In:Molecular biology and evolution: Oxford University Press (OUP)24:9, s. 2001-20080737-40381537-1719
Internet link
Find in a library
- Molecular biology and evolution (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Haitina, Tatjana
- Ringholm, Aneta
- Kelly, Joanne
- Mundy, Nicholas ...
- Schiöth, Helgi B ...
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- Articles in the publication
- Molecular biolog ...
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
