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Association of NCF2...
Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with Systemic Lupus Erythematosus
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Cunninghame Graham, Deborah S (författare)
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Morris, David L (författare)
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Bhangale, Tushar R (författare)
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Criswell, Lindsey A (författare)
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- Syvänen, Ann-Christine (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Rönnblom, Lars (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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Behrens, Timothy W (författare)
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Graham, Robert R (författare)
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Vyse, Timothy J (författare)
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(creator_code:org_t)
- 2011-10-27
- 2011
- Engelska.
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Ingår i: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404. ; 7:10, s. e1002341-
- Relaterad länk:
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https://journals.plo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Systemic lupus erythematosus (SLE) is a complex trait characterised by the production of a range of auto-antibodies and a diverse set of clinical phenotypes. Currently, ∼8% of the genetic contribution to SLE in Europeans is known, following publication of several moderate-sized genome-wide (GW) association studies, which identified loci with a strong effect (OR>1.3). In order to identify additional genes contributing to SLE susceptibility, we conducted a replication study in a UK dataset (870 cases, 5,551 controls) of 23 variants that showed moderate-risk for lupus in previous studies. Association analysis in the UK dataset and subsequent meta-analysis with the published data identified five SLE susceptibility genes reaching genome-wide levels of significance (P(comb)<5×10(-8)): NCF2 (P(comb) = 2.87×10(-11)), IKZF1 (P(comb) = 2.33×10(-9)), IRF8 (P(comb) = 1.24×10(-8)), IFIH1 (P(comb) = 1.63×10(-8)), and TYK2 (P(comb) = 3.88×10(-8)). Each of the five new loci identified here can be mapped into interferon signalling pathways, which are known to play a key role in the pathogenesis of SLE. These results increase the number of established susceptibility genes for lupus to ∼30 and validate the importance of using large datasets to confirm associations of loci which moderately increase the risk for disease.
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