The adhesion GPCRs : a unique family of G protein-coupled receptors with important roles in both central and peripheral tissues

• Gprotein-coupled receptors (GPCRs) are adiverse superfamily of membrane-bound receptors.The second largest subgroup of GPCRs, the AdhesionGPCRs, has 33 members in humans. Phylogeneticanalysis of the entire repertoire of the seven transmembrane-domain (7TM) regions of GPCRs showsthat the Adhesion GPCRs form a distinct family.Adhesion GPCRs are characterised by (1) long Ntermini with multiple functional domains often foundin other proteins such as tyrosine kinases, integrinsand cadherins, (2) highly complex genomic structurewith multiple introns and splice variants and (3) a7TMregion that has no clear similarities with 7TM fromother GPCRs. Several AdhesionGPCRs are known tohave a role in the immune system but it is becomingmore evident that many have important roles in theCNS. We speculate that the overall structural constructionof the Adhesion GPCRs allows them toparticipate in different types of cell guidance.

Nyckelord

Alternative Splicing

Amino Acid Sequence

Humans

Introns

Molecular Sequence Data

Phylogeny

Protein Binding

Protein Structure; Tertiary

Receptors; G-Protein-Coupled/chemistry/classification/genetics/*metabolism

Sequence Alignment

Tissue Distribution

MEDICINE

MEDICIN

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