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Decreased bone mine...
Decreased bone mineral density in young adults treated with SCT in childhood : the role of 25-hydroxyvitamin D
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- Frisk, Per, 1966- (författare)
- Uppsala universitet,Pediatrik,Barnonkologisk forskning/Pfeifer
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- Arvidson, Johan, 1953- (författare)
- Uppsala universitet,Pediatrik,Barnonkologisk forskning/Pfeifer
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- Ljunggren, Östen (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Metabola bensjukdomar
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- Gustafsson, Jan (författare)
- Uppsala universitet,Pediatrik,Barnendokrinologisk forskning/Gustafsson
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(creator_code:org_t)
- 2011-07-18
- 2012
- Engelska.
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Ingår i: Bone Marrow Transplantation. - : Springer Science and Business Media LLC. - 0268-3369 .- 1476-5365. ; 47:5, s. 657-662
- Relaterad länk:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We measured bone mineral density (BMD) with dual-energy X-ray absorptiometry in the total body, at the lumbar spine, at the femoral neck and in the total hip, in 18 young adults with a median of 18.2 years after SCT. Fifteen patients had undergone auto-SCT and all patients had received TBI. The patients had significantly lower BMD in the total body, at the femoral neck, and in the total hip compared with age- and sex-matched controls. Six of 18 patients (33%) had low bone mass (z-score <−1) at one or more measurement sites, as opposed to two of the controls (11%, P=0.29). We found no significant influence of growth hormone levels or of untreated hypogonadism on BMD variables. Levels of 25-hydroxy (25(OH)) vitamin D were lower among the patients (35.2 vs 48.8 nmol/L, P=0.044) and were significantly correlated with total body BMD in the patient group (r=0.55, P=0.021). All six patients with low bone mass had hypovitaminosis D (37 nmol/L as opposed to 4 of the 11 (36%) patients without low bone mass (P=0.035). In conclusion, we found decreased BMD in SCT survivors, which may in part be caused by 25(OH) vitamin D deficiency.
Nyckelord
- SCT
- bone mineral density
- dual-energy X-ray absorptiometry
- growth hormone
- 25(OH) vitamin D
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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