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  • Milan, Amber M.Univ Auckland, New Zealand (author)

Comparison of the impact of bovine milk beta-casein variants on digestive comfort in females self-reporting dairy intolerance : a randomized controlled trial

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • Oxford University Press,2020
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-163224
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-163224URI
  • https://doi.org/10.1093/ajcn/nqz279DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|New Zealand Ministry of Business, Innovation, and Employment (MBIE) through the High-Value Nutrition National Science Challenge (HVN); a2 Milk Company Ltd (a2MC)
  • Background: Lactose malabsorption (LM) is a major cause of digestive discomfort from dairy products. Recently. a role for bovine beta-casein A1 has been proposed. Objectives: We examined whether there are distinct symptoms of digestive discomfort due to either lactose or differing bovine beta-casein types. Methods: Women (n = 40; age: 25.2 +/- 05 y) with self-reported varying dairy tolerance underwent a 50-g lactose challenge. Based on postchallenge LM and digestive discomfort, participants were classified as either lactose intolerant (LI; n = 10, self-reported intolerant, diagnosed lactose intolerant), nonlactose dairy intolerant (NLDI; n = 20, self-reported intolerant, diagnosed lactose tolerant), or dairy tolerant (DT: n = 10, self-reported tolerant, diagnosed lactose tolerant). In a double-blinded randomized sequence, participants consumed 750 mL conventional milk (CON; containing Al and A2 beta-casein and lactose), a2 Milk (A2M; exclusively containing A2 beta-casein with lactose), or lactose-free conventional milk (LF-CON; containing Al and A2 beta-casein without lactose). Subjective digestive symptoms and breath hydrogen (measuring LM) were recorded regularly over 3 h, and further ad hoc digestive symptoms over 12 h. Results: LI subjects experienced prolonged digestive discomfort with CON milk. A2M reduced (P amp;lt; 0.05) some symptoms (nausea: A2M 8 +/- 3 mm compared with CON 15 +/- 3mm: fecal urgency: A2M 4 +/- 1 compared with CON 10 +/- 3 mm), and attenuated the rise in breath hydrogen over 3 h, relative to CON milk (A2M 59 +/- 23 compared with CON 98 +/- 25 ppm at 150 min; P amp;lt; 0.01). In contrast, NLDI subjects experienced rapid-onset, transient symptoms (abdominal distension, bloating, and flatulence) without increased breath hydrogen, irrespective of milk type. Conclusions: In LI individuals, LM and digestive comfort with lactose-containing milks was improved with milk containing exclusively A2 beta-casein. Furthermore, self-reported dairy intolerance without LM (NLDI) is characterized by early-onset digestive discomfort following milk ingestion, irrespective of lactose content or beta-casein type.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Shrestha, AahanaUniv Auckland, New Zealand (author)
  • Karlstrom, Helga J.Linköpings universitet(Swepub:liu)n/a (author)
  • Martinsson, Jakob A.Linköpings universitet(Swepub:liu)n/a (author)
  • Nilsson, Nils J.Linköpings universitet(Swepub:liu)n/a (author)
  • Perry, Jo K.Univ Auckland, New Zealand (author)
  • Day, LiAgResearch Ltd, New Zealand (author)
  • Barnett, Matthew P. G.AgResearch Ltd, New Zealand; Riddet Inst, New Zealand; High Value Nutr Natl Sci Challenge, New Zealand (author)
  • Cameron-Smith, DavidUniv Auckland, New Zealand; AgResearch Ltd, New Zealand; Riddet Inst, New Zealand (author)
  • Linköpings universitetUniv Auckland, New Zealand (creator_code:org_t)

Related titles

  • In:American Journal of Clinical Nutrition: Oxford University Press111:1, s. 149-1600002-91651938-3207

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