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  • Johansson, AndersUppsala universitet,Neurologi (author)

[11C]-PIB imaging in patients with Parkinson's disease : preliminary results

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • Elsevier BV,2008
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-16636
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-16636URI
  • https://doi.org/10.1016/j.parkreldis.2007.07.010DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:117345194URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • [11C]-PIB positron emission tomography ([11C]-PIB PET) is a sensitive marker of amyloid in Alzheimer's disease (AD), but its specificity has not been fully evaluated. Vascular amyloid-β deposition is common in Parkinson's disease (PD) and α-synuclein, the major component of the Lewy bodies in PD, forms amyloid fibrils. We investigated five apparently cognitively normal PD patients with [11C]-PIB PET. The results were compared to 16 patients with AD and six healthy controls from a previous study. [11C]-PIB retention was not significantly increased in our patients who all had early stage PD. Further studies of more advanced PD patients are warranted.

Subject headings and genre

  • Parkinson's disease
  • PET
  • PIB
  • Amyloid
  • Lewy bodies
  • α-Synuclein

Added entries (persons, corporate bodies, meetings, titles ...)

  • Savitcheva, IrinaUppsala universitet,Institutionen för medicinska vetenskaper (author)
  • Forsberg, AndersKarolinska Institutet(Swepub:uu)andfo758 (author)
  • Engler, HenryUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)henrengl (author)
  • Långström, Bengt (author)
  • Nordberg, Agneta (author)
  • Askmark, HåkanUppsala universitet,Neurologi(Swepub:uu)hakaaskm (author)
  • Uppsala universitetNeurologi (creator_code:org_t)

Related titles

  • In:Parkinsonism & Related Disorders: Elsevier BV14:4, s. 345-3471353-80201873-5126

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