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Sökning: WFRF:(Aili M) > Polypeptide Folding...

  • Aili, DanielUniversity of London Imperial College of Science Technology and Medicine (författare)

Polypeptide Folding-Mediated Tuning of the Optical and Structural Properties of Gold Nanoparticle Assemblies

  • Artikel/kapitelEngelska2011

Förlag, utgivningsår, omfång ...

  • 2011-11-08
  • American Chemical Society (ACS),2011
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-166733
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-166733URI
  • https://doi.org/10.1021/nl203559sDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-73736URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Responsive hybrid nanomaterials with well-defined properties are of significant interest for the development of biosensors with additional applications in tissue engineering and drug delivery. Here, we present a detailed characterization using UV-vis spectroscopy and small angle X-ray scattering of a hybrid material comprised of polypeptide-decorated gold nanoparticles with highly controllable assembly properties. The assembly is triggered by a folding-dependent bridging of the particles mediated by the heteroassociation of immobilized helix-loop-helix polypeptides and a complementary nonlinear polypeptide present in solution. The polypeptides are de novo designed to associate and fold into a heterotrimeric complex comprised of two disulfide-linked four-helix bundles. The particles form structured assemblies with a highly defined interparticle gap (4.8 +/- 0.4 nm) that correlates to the size of the folded polypeptides. Transitions in particle aggregation dynamics, mass-fractal dimensions and ordering, as a function of particle size and the concentration of the bridging polypeptide, are observed; these have significant effects on the optical properties of the assemblies. The assembly and ordering of the particles are highly complex processes that are affected by a large number of variables including the number of polypeptides bridging the particles and the particle mobility within the aggregates. A fundamental understanding of these processes is of paramount interest for the development of novel hybrid nanomaterials with tunable structural and optical properties and for the optimization of nanoparticle-based colorimetric biodetection strategies.

Ämnesord och genrebeteckningar

  • Gold nanoparticles
  • polypeptides
  • folding
  • helix-loop-helix
  • small angle X-ray scattering (SAXS)
  • MEDICINE

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Gryko, PiotrUniversity of London Imperial College of Science Technology and Medicine (författare)
  • Sepulveda, BorjaResearch Centre Nanosci and Nanotechnol CIN2 CSIC (författare)
  • Dick, John A. G.University of London Imperial College of Science Technology and Medicine (författare)
  • Kirby, NigelAustralian Synchrotron (författare)
  • Heenan, RichardRutherford Appleton Lab (författare)
  • Baltzer, LarsUppsala universitet,Institutionen för biokemi och organisk kemi,Uppsala University(Swepub:uu)labal087 (författare)
  • Liedberg, BoLinköpings universitet,Sensorvetenskap och Molekylfysik,Tekniska högskolan(Swepub:liu)boli31 (författare)
  • Ryan, Mary P.University of London Imperial College of Science Technology and Medicine (författare)
  • Stevens, Molly M.University of London Imperial College of Science Technology and Medicine (författare)
  • University of London Imperial College of Science Technology and MedicineResearch Centre Nanosci and Nanotechnol CIN2 CSIC (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Nano letters (Print): American Chemical Society (ACS)11:12, s. 5564-55731530-69841530-6992

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