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  • Mertes, Florian (author)

Targeted enrichment of genomic DNA regions for next-generation sequencing

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2011-11-26
  • Oxford University Press (OUP),2011
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-167667
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-167667URI
  • https://doi.org/10.1093/bfgp/elr033DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:for swepub-publicationtype

Notes

  • In this review, we discuss the latest targeted enrichment methods and aspects of their utilization along with second-generation sequencing for complex genome analysis. In doing so, we provide an overview of issues involved in detecting genetic variation, for which targeted enrichment has become a powerful tool. We explain how targeted enrichment for next-generation sequencing has made great progress in terms of methodology, ease of use and applicability, but emphasize the remaining challenges such as the lack of even coverage across targeted regions. Costs are also considered versus the alternative of whole-genome sequencing which is becoming ever more affordable. We conclude that targeted enrichment is likely to be the most economical option for many years to come in a range of settings.

Subject headings and genre

  • targeted enrichment
  • next-generation sequencing
  • genome partitioning
  • exome
  • genetic variation

Added entries (persons, corporate bodies, meetings, titles ...)

  • ElSharawy, Abdou (author)
  • Sauer, Sascha (author)
  • van Helvoort, Joop M. L. M. (author)
  • van der Zaag, P. J. (author)
  • Franke, Andre (author)
  • Nilsson, MatsUppsala universitet,Molekylära verktyg(Swepub:uu)matsnils (author)
  • Lehrach, Hans (author)
  • Brookes, Anthony J. (author)
  • Uppsala universitetMolekylära verktyg (creator_code:org_t)

Related titles

  • In:Briefings in functional genomics: Oxford University Press (OUP)10:6, s. 374-3862041-26492041-2657

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