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Lung function, resp...
Lung function, respiratory symptoms, and the menopausal transition
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Real, Francisco Gómez (författare)
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Svanes, Cecilie (författare)
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Omenaas, Ernst Reidar (författare)
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visa fler...
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Antò, Josep Maria (författare)
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Plana, Estel (författare)
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Jarvis, Deborah (författare)
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- Janson, Christer (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Lungmedicin och allergologi
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Neukirch, Françoise (författare)
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Zemp, Elisabeth (författare)
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Dratva, Julia (författare)
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Wjst, Matthias (författare)
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Svanes, Knut (författare)
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Leynaert, Bénédicte (författare)
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Sunyer, Jordi (författare)
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visa färre...
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(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- Engelska.
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Ingår i: Journal of Allergy and Clinical Immunology. - : Elsevier BV. - 0091-6749 .- 1097-6825. ; 121:1, s. 72-80.e3
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: There is limited information on potential changes in respiratory health when women enter the menopausal transition. OBJECTIVE: We sought to investigate whether the menopausal transition is related to lung function and asthma and whether body mass index (BMI) modifies associations. METHODS: Four thousand two hundred fifty-nine women from 21 centers (ECRHS II, 2002) responded to a questionnaire concerning women's health. Women aged 45 to 56 years not using exogenous sex hormones (n = 1274) were included in the present analysis. Lung function measurements (n = 1120) and serum markers of hormonal status (follicle-stimulating hormone, luteinizing hormone, and estradiol; n = 710) were available. Logistic and linear regression analyses were adjusted for BMI, age, years of education, smoking status, center, and height. RESULTS: Women not menstruating for the last 6 months (n = 432, 34%) had significantly lower FEV(1) values (-120 mL [95% CI, -177 to -63]), lower forced vital capacity values (-115 mL [95% CI, -181 to -50]), and more respiratory symptoms (odds ratio [OR], 1.82 [95% CI, 1.27-2.61]) than those menstruating regularly. Results were similar when restricting analyses to those who never smoked. Associations were significantly stronger in women with BMIs of less than 23 kg/m(2) (respiratory symptoms: OR, 4.07 [95% CI, 1.88-8.80]; FEV(1) adjusted difference: -166 [95% CI, -263 to -70]) than in women with BMIs of 23 to 28 kg/m(2) (respiratory symptoms: OR, 1.10 [95% CI, 0.61-1.97], P(interaction): .04; FEV(1) adjusted difference, -54 [95% CI, -151 to 43], P(interaction) = .06). CONCLUSIONS: Menopause is associated with lower lung function and more respiratory symptoms, especially among lean women.
Nyckelord
- Asthma/epidemiology
- Body Mass Index
- Female
- Forced Expiratory Volume
- Humans
- Hypersensitivity/epidemiology/etiology
- Menopause
- Middle Aged
- Respiration Disorders/epidemiology/etiology
- Respiratory Function Tests
- Respiratory Physiology
- Vital Capacity
- Women's Health
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Real, Francisco ...
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Svanes, Cecilie
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Omenaas, Ernst R ...
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Antò, Josep Mari ...
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Plana, Estel
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Jarvis, Deborah
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visa fler...
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Janson, Christer
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Neukirch, Franço ...
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Zemp, Elisabeth
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Dratva, Julia
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Wjst, Matthias
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Svanes, Knut
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Leynaert, Bénédi ...
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Sunyer, Jordi
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visa färre...
- Artiklar i publikationen
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Journal of Aller ...
- Av lärosätet
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Uppsala universitet