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Weight of evidence evaluation of the metabolism disrupting effects of triphenyl phosphate using an expert knowledge elicitation approach

Beausoleil, Claire (författare)
French Agency for Food, Environmental and Occupational Health and Safety (Anses), Maisons-Alfort, France
Thébault, Anne (författare)
French Agency for Food, Environmental and Occupational Health and Safety (Anses), Maisons-Alfort, France
Andersson, Patrik L. (författare)
Umeå universitet,Kemiska institutionen
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Cabaton, Nicolas J. (författare)
INRAE. UMR1331 Toxalim (Research Center in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UT3, Toulouse, France
Ermler, Sibylle (författare)
Department of Life Sciences, Centre of Genome Engineering and Maintenance, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge, United Kingdom
Fromenty, Bernard (författare)
INSERM, Univ Rennes, INRAE, Institut NUMECAN (Nutrition Metabolisms and Cancer) UMR_A 1341, UMR_S 1317, Rennes, France
Garoche, Clémentine (författare)
Institut de Recherche en Cancérologie de Montpellier (IRCM), Inserm U1194, Université Montpellier, Institut Régional du Cancer de Montpellier (ICM), Montpellier, France
Griffin, Julian L. (författare)
The Rowett Institute, Foresterhill Health Campus, University of Aberdeen, Aberdeen, United Kingdom
Hoffmann, Sebastian (författare)
Seh Consulting + Services, Stembergring 15, Paderborn, Germany
Kamstra, Jorke H. (författare)
Institute for Risk Assessment Sciences, Department of Population Health Sciences, Utrecht University, Utrecht, Netherlands
Kubickova, Barbara (författare)
Radiation, Chemical and Environmental Hazards (RCE), Department of Toxicology, UK Health Security Agency (UKHSA), Harwell Science and Innovation Campus, Oxon, Chilton, United Kingdom
Lenters, Virissa (författare)
Institute for Risk Assessment Sciences, Department of Population Health Sciences, Utrecht University, Utrecht, Netherlands
Kos, Vesna Munic (författare)
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Poupin, Nathalie (författare)
INRAE. UMR1331 Toxalim (Research Center in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UT3, Toulouse, France
Remy, Sylvie (författare)
Flemish Institute for Technological Research (VITO), Mol, Belgium
Sapounidou, Maria (författare)
Umeå universitet,Kemiska institutionen
Zalko, Daniel (författare)
INRAE. UMR1331 Toxalim (Research Center in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UT3, Toulouse, France
Legler, Juliette (författare)
Institute for Risk Assessment Sciences, Department of Population Health Sciences, Utrecht University, Utrecht, Netherlands
Jacobs, Miriam N. (författare)
Radiation, Chemical and Environmental Hazards (RCE), Department of Toxicology, UK Health Security Agency (UKHSA), Harwell Science and Innovation Campus, Oxon, Chilton, United Kingdom
Rousselle, Christophe (författare)
French Agency for Food, Environmental and Occupational Health and Safety (Anses), Maisons-Alfort, France
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 (creator_code:org_t)
Elsevier, 2024
2024
Engelska.
Ingår i: Toxicology and Applied Pharmacology. - : Elsevier. - 0041-008X .- 1096-0333. ; 489
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Identification of Endocrine-Disrupting Chemicals (EDCs) in a regulatory context requires a high level of evidence. However, lines of evidence (e.g. human, in vivo, in vitro or in silico) are heterogeneous and incomplete for quantifying evidence of the adverse effects and mechanisms involved. To date, for the regulatory appraisal of metabolism-disrupting chemicals (MDCs), no harmonised guidance to assess the weight of evidence has been developed at the EU or international level. To explore how to develop this, we applied a formal Expert Knowledge Elicitation (EKE) approach within the European GOLIATH project. EKE captures expert judgment in a quantitative manner and provides an estimate of uncertainty of the final opinion. As a proof of principle, we selected one suspected MDC -triphenyl phosphate (TPP) - based on its related adverse endpoints (obesity/adipogenicity) relevant to metabolic disruption and a putative Molecular Initiating Event (MIE): activation of peroxisome proliferator activated receptor gamma (PPARγ). We conducted a systematic literature review and assessed the quality of the lines of evidence with two independent groups of experts within GOLIATH, with the objective of categorising the metabolic disruption properties of TPP, by applying an EKE approach. Having followed the entire process separately, both groups arrived at the same conclusion, designating TPP as a “suspected MDC” with an overall quantitative agreement exceeding 85%, indicating robust reproducibility. The EKE method provides to be an important way to bring together scientists with diverse expertise and is recommended for future work in this area.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)

Nyckelord

Elicitation
Metabolism-disrupting chemicals
Obesity
PPARγ
Triphenyl phosphate (TPP)
Weight of evidence

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