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  • Gemoll, TimoDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles va¨g 2, 17177 Stockholm, Sweden (author)

Protein profiling of genomic instability in endometrial cancer

  • Article/chapterEnglish2012

Publisher, publication year, extent ...

  • 2011-07-08
  • Springer,2012
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-168100
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-168100URI
  • https://doi.org/10.1007/s00018-011-0752-0DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:123833563URI

Supplementary language notes

  • Language:English
  • Summary in:English &language:-1_t

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • DNA aneuploidy has been identified as a prognostic factor in the majority of epithelial malignancies. We aimed at identifying ploidy-associated protein expression in endometrial cancer of different prognostic subgroups. Comparison of gel electrophoresis-based protein expression patterns between normal endometrium (n = 5), diploid (n = 7), and aneuploid (n = 7) endometrial carcinoma detected 121 ploidy-associated protein forms, 42 differentially expressed between normal endometrium and diploid endometrioid carcinomas, 37 between diploid and aneuploid endometrioid carcinomas, and 41 between diploid endometrioid and aneuploid uterine papillary serous cancer. Proteins were identified by mass spectrometry and evaluated by Ingenuity Pathway Analysis. Targets were confirmed by liquid chromatography/mass spectrometry. Mass spectrometry identified 41 distinct polypeptides and pathway analysis resulted in high-ranked networks with vimentin and Nf-kappa B as central nodes. These results identify ploidy-associated protein expression differences that overrule histopathology-associated expression differences and emphasize particular protein networks in genomic stability of endometrial cancer.

Subject headings and genre

  • Aneuploidy
  • Endometrial carcinoma
  • Genomic instability
  • Mass spectrometry
  • Pathway analysis
  • Two-dimensional gel electrophoresis

Added entries (persons, corporate bodies, meetings, titles ...)

  • Habermann, Jens K.Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles va¨g 2, 17177 Stockholm, Sweden (author)
  • Lahmann, JohannaDepartment of Surgery, University of Lu¨beck, 23538 Lu¨beck, Germany (author)
  • Szymczak, SilkeInstitute of Medical Biometry and Statistics, University of Lu¨beck, 23562 Lu¨beck, Germany (author)
  • Lundgren, CarolineDepartment of Oncology, Radiumhemmet, Karolinska University Hospital, 17176 Stockholm, Sweden (author)
  • Bündgen, Nana K.Department of Surgery, University of Lu¨beck, 23538 Lu¨beck, Germany (author)
  • Jungbluth, ThomasDepartment of Surgery, University of Lu¨beck, 23538 Lu¨beck, Germany (author)
  • Nordström, BrittaDepartment of Oncology, Radiumhemmet, Karolinska University Hospital, 17176 Stockholm, Sweden (author)
  • Becker, SusanneKarolinska Biomic Center, Karolinska Institutet, 17176 Stockholm, Sweden (author)
  • Lomnytska, Marta I.Karolinska Institutet(Swepub:uu)marlo829 (author)
  • Bruch, Hans-PeterDepartment of Surgery, University of Lu¨beck, 23538 Lu¨beck, Germany (author)
  • Ziegler, AndreasInstitute of Medical Biometry and Statistics, University of Lu¨beck, 23562 Lu¨beck, Germany (author)
  • Hellman, UlfUppsala universitet,Ludwiginstitutet för cancerforskning(Swepub:uu)ulfhm (author)
  • Auer, GertKarolinska Institutet (author)
  • Roblick, Uwe J.Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles va¨g 2, 17177 Stockholm, Sweden (author)
  • Jörnvall, HansKarolinska Institutet (author)
  • Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles va¨g 2, 17177 Stockholm, SwedenDepartment of Surgery, University of Lu¨beck, 23538 Lu¨beck, Germany (creator_code:org_t)

Related titles

  • In:Cellular and Molecular Life Sciences (CMLS): Springer69:2, s. 325-3331420-682X1420-9071

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