Sökning: WFRF:(Auer Gert)
> (2010-2014) >
Protein profiling o...
Protein profiling of genomic instability in endometrial cancer
-
- Gemoll, Timo (författare)
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles va¨g 2, 17177 Stockholm, Sweden
-
- Habermann, Jens K. (författare)
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles va¨g 2, 17177 Stockholm, Sweden
-
- Lahmann, Johanna (författare)
- Department of Surgery, University of Lu¨beck, 23538 Lu¨beck, Germany
-
visa fler...
-
- Szymczak, Silke (författare)
- Institute of Medical Biometry and Statistics, University of Lu¨beck, 23562 Lu¨beck, Germany
-
- Lundgren, Caroline (författare)
- Department of Oncology, Radiumhemmet, Karolinska University Hospital, 17176 Stockholm, Sweden
-
- Bündgen, Nana K. (författare)
- Department of Surgery, University of Lu¨beck, 23538 Lu¨beck, Germany
-
- Jungbluth, Thomas (författare)
- Department of Surgery, University of Lu¨beck, 23538 Lu¨beck, Germany
-
- Nordström, Britta (författare)
- Department of Oncology, Radiumhemmet, Karolinska University Hospital, 17176 Stockholm, Sweden
-
- Becker, Susanne (författare)
- Karolinska Biomic Center, Karolinska Institutet, 17176 Stockholm, Sweden
-
- Lomnytska, Marta I. (författare)
- Karolinska Institutet
-
- Bruch, Hans-Peter (författare)
- Department of Surgery, University of Lu¨beck, 23538 Lu¨beck, Germany
-
- Ziegler, Andreas (författare)
- Institute of Medical Biometry and Statistics, University of Lu¨beck, 23562 Lu¨beck, Germany
-
- Hellman, Ulf (författare)
- Uppsala universitet,Ludwiginstitutet för cancerforskning
-
- Auer, Gert (författare)
- Karolinska Institutet
-
- Roblick, Uwe J. (författare)
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles va¨g 2, 17177 Stockholm, Sweden
-
- Jörnvall, Hans (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- 2011-07-08
- 2012
- Engelska.
-
Ingår i: Cellular and Molecular Life Sciences (CMLS). - : Springer. - 1420-682X .- 1420-9071. ; 69:2, s. 325-333
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- DNA aneuploidy has been identified as a prognostic factor in the majority of epithelial malignancies. We aimed at identifying ploidy-associated protein expression in endometrial cancer of different prognostic subgroups. Comparison of gel electrophoresis-based protein expression patterns between normal endometrium (n = 5), diploid (n = 7), and aneuploid (n = 7) endometrial carcinoma detected 121 ploidy-associated protein forms, 42 differentially expressed between normal endometrium and diploid endometrioid carcinomas, 37 between diploid and aneuploid endometrioid carcinomas, and 41 between diploid endometrioid and aneuploid uterine papillary serous cancer. Proteins were identified by mass spectrometry and evaluated by Ingenuity Pathway Analysis. Targets were confirmed by liquid chromatography/mass spectrometry. Mass spectrometry identified 41 distinct polypeptides and pathway analysis resulted in high-ranked networks with vimentin and Nf-kappa B as central nodes. These results identify ploidy-associated protein expression differences that overrule histopathology-associated expression differences and emphasize particular protein networks in genomic stability of endometrial cancer.
Nyckelord
- Aneuploidy
- Endometrial carcinoma
- Genomic instability
- Mass spectrometry
- Pathway analysis
- Two-dimensional gel electrophoresis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Gemoll, Timo
-
Habermann, Jens ...
-
Lahmann, Johanna
-
Szymczak, Silke
-
Lundgren, Caroli ...
-
Bündgen, Nana K.
-
visa fler...
-
Jungbluth, Thoma ...
-
Nordström, Britt ...
-
Becker, Susanne
-
Lomnytska, Marta ...
-
Bruch, Hans-Pete ...
-
Ziegler, Andreas
-
Hellman, Ulf
-
Auer, Gert
-
Roblick, Uwe J.
-
Jörnvall, Hans
-
visa färre...
- Artiklar i publikationen
-
Cellular and Mol ...
- Av lärosätet
-
Uppsala universitet
-
Karolinska Institutet