[Immunohistochemical study of P-cadherin in breast cancer].: P-cadherin immunhisztokémiai vizsgálata emlórákokban.

Kovács, Anikó,1961Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin , Avdelningen för patologi,Institute of Laboratory Medicine, Dept of Pathology (author)

[Immunohistochemical study of P-cadherin in breast cancer]. : P-cadherin immunhisztokémiai vizsgálata emlórákokban.

Cell adhesion molecules play a significant role in the cellular connection of normal cells. The cadherins are believed to act as tumour suppressors, and their altered expression and function have been associated with tumour development.The authors examined the expression of a Ca++ dependent intercellular adhesion molecule, P-cadherin using an immunohistochemical method in 69 surgically resected breast carcinomas.P-cadherin was detected in 30 cases (43.5%, cytoplasmic and/or membrane staining). The expression of P-cadherin was independent of tumour size and lymph node status, but correlated with a high tumour grade (grade III). In contrast, expression of E-cadherin correlated with lower tumour grade (grade I-II). P-cadherin expression was not detected in invasive lobular carcinomas.In general, P-cadherin was expressed at a lower frequency compared to E-cadherin, alpha-, and beta-catenin. These results suggest that an inverse relationship may exist between E- and P-cadherin in relation to grade, and that the expression of P-cadherin may be a marker of aggressiveness.

MEDICIN OCH HÄLSOVETENSKAP Medicinsk bioteknologi Biomedicinsk laboratorievetenskap/teknologi hsv//swe
MEDICAL AND HEALTH SCIENCES Medical Biotechnology Biomedical Laboratory Science/Technology hsv//eng
Breast Neoplasms
chemistry
pathology
Cadherins
analysis
Carcinoma
Ductal
Breast
chemistry
pathology
Female
Gene Expression Regulation
Neoplastic
Humans
Immunohistochemistry
Receptors
Estrogen
analysis
Receptors
Progesterone
analysis

Walker, Rosemary A (author)
Nagy, András (author)
Gomba, Szabolcs (author)
Jones, Louise (author)
Dearing, Sheila (author)
Göteborgs universitetInstitutionen för laboratoriemedicin , Avdelningen för patologi (creator_code:org_t)

By the author/editor: Kovács, Anikó, 1 ...; Walker, Rosemary ...; Nagy, András; Gomba, Szabolcs; Jones, Louise; Dearing, Sheila

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Medical Biotechn ...; and Biomedical Labor ...

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