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Isoflavones and Rot...
Isoflavones and Rotenoids from the Leaves of Millettia oblata ssp teitensis
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- Deyou, Tsegaye (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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Marco, M. (author)
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Heydenreich, M. (author)
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Pan, F. F. (author)
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- Gruhonjic, Amra (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Sahlgrenska Cancer Center,Department of Chemistry and Molecular Biology
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- Fitzpatrick, Paul A. (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
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Koch, A. (author)
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Derese, S. (author)
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Pelletier, J. (author)
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Rissanen, K. (author)
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Yenesew, A. (author)
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- Erdelyi, Mate, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,organisk kemi
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(creator_code:org_t)
- 2017-06-30
- 2017
- English.
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In: Journal of Natural Products. - : American Chemical Society (ACS). - 0163-3864 .- 1520-6025. ; 80:7, s. 2060-2066
- Related links:
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https://pubs.acs.org...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- A new isoflavone, 8-prenylmilldrone (1), and four new rotenoids, oblarotenoids A-D (2-5), along with nine known compounds (6-14), were isolated from the CH2Cl2/CH3OH (1:1) extract of the leaves of Millettia oblata ssp. teitensis by chromatographic separation. The purified compounds were identified by NMR spectroscopic and mass spectrometric analyses, whereas the absolute configurations of the rotenoids were established on the basis of chiroptical data and in some cases by single-crystal X-ray crystallography. Maximaisoflavone J (11) and oblarotenoid C (4) showed weak activity against the human breast cancer cell line MDA-MB-231 with IC50 values of 33.3 and 93.8 mu M, respectively.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Keyword
- circular-dichroism
- derris-trifoliata
- root bark
- flavonoids
- derivatives
- density
- 12a-hydroxyrotenoids
- constituents
- usaramensis
- elucidation
- Plant Sciences
- Pharmacology & Pharmacy
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Deyou, Tsegaye
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Marco, M.
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Heydenreich, M.
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Pan, F. F.
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Gruhonjic, Amra
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Fitzpatrick, Pau ...
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show more...
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Koch, A.
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Derese, S.
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Pelletier, J.
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Rissanen, K.
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Yenesew, A.
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Erdelyi, Mate, 1 ...
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MEDICAL AND HEAL ...
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and Other Basic Medi ...
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- By the university
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University of Gothenburg
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Uppsala University