Evaluation of circulating concentrations of glucose homeostasis biomarkers, progesterone, and growth hormone in healthy Elkhounds during anestrus and diestrus

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Mared, Malin (author)

Evaluation of circulating concentrations of glucose homeostasis biomarkers, progesterone, and growth hormone in healthy Elkhounds during anestrus and diestrus

Article/chapterEnglish2012

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American Veterinary Medical Association (AVMA),2012
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LIBRIS-ID:oai:DiVA.org:uu-169336
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-169336URI
https://doi.org/10.2460/ajvr.73.2.242DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:123970051URI
https://res.slu.se/id/publ/45762URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Objective: To investigate whether circulating concentrations of biomarkers of glucose homeostasis, progesterone, and growth hormone in healthy female Elkhounds differ during diestrus and anestrus and to compare those findings with data from dogs of other breeds.Animals: 22 healthy female dogs of Elkhound breeds (known to have a high incidence of diestrus-associated diabetes mellitus) and 18 healthy female non-Elkhound dogs.Procedures: For each dog, a blood sample (12 mL) was collected once during anestrus and once 2 to 8 weeks after cessation of estrual bleeding. Serum or whole blood samples were analyzed for glucose, growth hormone, insulin-like growth factor-1, C-peptide, fructosamine, and glycated hemoglobin A1c concentrations. Homeostasis model assessments (HOMAs) of pancreatic beta-cell function and insulin secretion were calculated.Results: In Elkhounds, C-peptide concentration and the HOMA for beta-cell function (markers of insulin secretion) were higher in samples obtained during diestrus, compared with findings in samples obtained during anestrus. The HOMA for insulin sensitivity was lower (albeit not significantly) during diestrus than it was during anestrus in Elkhounds. Markers of insulin secretion and sensitivity were similar during anestrus and diestrus in the dogs of other breeds. Serum progesterone concentrations were greater during diestrus than during anestrus in Elkhounds and non-Elkhound dogs. All other variables did not differ between diestrus and anestrus within or between the 2 breed groupings.Conclusions and Clinical Relevance: Results provided evidence that circulating insulin concentrations during diestrus are higher than those during anestrus in Elkhounds, which could contribute to development of diestrus-associated diabetes mellitus.

Subject headings and genre

LANTBRUKSVETENSKAPER Veterinärmedicin hsv//swe
AGRICULTURAL SCIENCES Veterinary Science hsv//eng
LANTBRUKSVETENSKAPER Veterinärmedicin Klinisk vetenskap hsv//swe
AGRICULTURAL SCIENCES Veterinary Science Clinical Science hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Catchpole, Brian (author)
Kämpe, OlleUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)ollekamp (author)
Fall, Tove,1979-Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Karolinska Institutet,,University Animal Hospital(Swepub:slu)52224 (author)
Uppsala universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)
Sveriges lantbruksuniversitet

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In:American Journal of Veterinary Research: American Veterinary Medical Association (AVMA)73:2, s. 242-2470002-96451943-5681

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AGRICULTURAL SCIENCES: AGRICULTURAL SCI ...; and Veterinary Scien ...; and Clinical Science

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