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Search: WFRF:(Wright Harry H) > A genome-wide assoc...

A genome-wide association search for type 2 diabetes genes in African Americans.

Palmer, Nicholette D (author)
McDonough, Caitrin W (author)
Hicks, Pamela J (author)
show more...
Roh, Bong H (author)
Wing, Maria R (author)
An, S Sandy (author)
Hester, Jessica M (author)
Cooke, Jessica N (author)
Bostrom, Meredith A (author)
Rudock, Megan E (author)
Talbert, Matthew E (author)
Lewis, Joshua P (author)
Ferrara, Assiamira (author)
Lu, Lingyi (author)
Ziegler, Julie T (author)
Sale, Michele M (author)
Divers, Jasmin (author)
Shriner, Daniel (author)
Adeyemo, Adebowale (author)
Rotimi, Charles N (author)
Ng, Maggie C Y (author)
Langefeld, Carl D (author)
Freedman, Barry I (author)
Bowden, Donald W (author)
Voight, Benjamin F (author)
Scott, Laura J (author)
Steinthorsdottir, Valgerdur (author)
Morris, Andrew P (author)
Dina, Christian (author)
Welch, Ryan P (author)
Zeggini, Eleftheria (author)
Huth, Cornelia (author)
Aulchenko, Yurii S (author)
Thorleifsson, Gudmar (author)
McCulloch, Laura J (author)
Ferreira, Teresa (author)
Grallert, Harald (author)
Amin, Najaf (author)
Wu, Guanming (author)
Willer, Cristen J (author)
Raychaudhuri, Soumya (author)
McCarroll, Steve A (author)
Langenberg, Claudia (author)
Hofmann, Oliver M (author)
Dupuis, Josée (author)
Qi, Lu (author)
Segrè, Ayellet V (author)
van Hoek, Mandy (author)
Navarro, Pau (author)
Ardlie, Kristin (author)
Balkau, Beverley (author)
Benediktsson, Rafn (author)
Bennett, Amanda J (author)
Blagieva, Roza (author)
Boerwinkle, Eric (author)
Bonnycastle, Lori L (author)
Boström, Kristina Bengtsson (author)
Bravenboer, Bert (author)
Bumpstead, Suzannah (author)
Burtt, Noël P (author)
Charpentier, Guillaume (author)
Chines, Peter S (author)
Cornelis, Marilyn (author)
Couper, David J (author)
Crawford, Gabe (author)
Doney, Alex S F (author)
Elliott, Katherine S (author)
Elliott, Amanda L (author)
Erdos, Michael R (author)
Fox, Caroline S (author)
Franklin, Christopher S (author)
Ganser, Martha (author)
Gieger, Christian (author)
Grarup, Niels (author)
Green, Todd (author)
Griffin, Simon (author)
Groves, Christopher J (author)
Guiducci, Candace (author)
Hadjadj, Samy (author)
Hassanali, Neelam (author)
Herder, Christian (author)
Isomaa, Bo (author)
Jackson, Anne U (author)
Johnson, Paul R V (author)
Jørgensen, Torben (author)
Kao, Wen H L (author)
Klopp, Norman (author)
Kong, Augustine (author)
Kraft, Peter (author)
Kuusisto, Johanna (author)
Lauritzen, Torsten (author)
Li, Man (author)
Lieverse, Aloysius (author)
Lindgren, Cecilia M (author)
Lyssenko, Valeriya (author)
Marre, Michel (author)
Meitinger, Thomas (author)
Midthjell, Kristian (author)
Morken, Mario A (author)
Narisu, Narisu (author)
Nilsson, Peter (author)
Owen, Katharine R (author)
Payne, Felicity (author)
Perry, John R B (author)
Petersen, Ann-Kristin (author)
Platou, Carl (author)
Proença, Christine (author)
Prokopenko, Inga (author)
Rathmann, Wolfgang (author)
Rayner, N William (author)
Robertson, Neil R (author)
Rocheleau, Ghislain (author)
Roden, Michael (author)
Sampson, Michael J (author)
Saxena, Richa (author)
Shields, Beverley M (author)
Shrader, Peter (author)
Sigurdsson, Gunnar (author)
Sparsø, Thomas (author)
Strassburger, Klaus (author)
Stringham, Heather M (author)
Sun, Qi (author)
Swift, Amy J (author)
Thorand, Barbara (author)
Tichet, Jean (author)
Tuomi, Tiinamaija (author)
van Dam, Rob M (author)
van Haeften, Timon W (author)
van Herpt, Thijs (author)
van Vliet-Ostaptchouk, Jana V (author)
Walters, G Bragi (author)
Weedon, Michael N (author)
Wijmenga, Cisca (author)
Witteman, Jacqueline (author)
Bergman, Richard N (author)
Cauchi, Stephane (author)
Collins, Francis S (author)
Gloyn, Anna L (author)
Gyllensten, Ulf (author)
Hansen, Torben (author)
Hide, Winston A (author)
Hitman, Graham A (author)
Hofman, Albert (author)
Hunter, David J (author)
Hveem, Kristian (author)
Laakso, Markku (author)
Mohlke, Karen L (author)
Morris, Andrew D (author)
Palmer, Colin N A (author)
Pramstaller, Peter P (author)
Rudan, Igor (author)
Sijbrands, Eric (author)
Stein, Lincoln D (author)
Tuomilehto, Jaakko (author)
Uitterlinden, Andre (author)
Walker, Mark (author)
Wareham, Nicholas J (author)
Watanabe, Richard M (author)
Abecasis, Goncalo R (author)
Boehm, Bernhard O (author)
Campbell, Harry (author)
Daly, Mark J (author)
Hattersley, Andrew T (author)
Hu, Frank B (author)
Meigs, James B (author)
Pankow, James S (author)
Pedersen, Oluf (author)
Wichmann, H-Erich (author)
Barroso, Inês (author)
Florez, Jose C (author)
Frayling, Timothy M (author)
Groop, Leif (author)
Sladek, Rob (author)
Thorsteinsdottir, Unnur (author)
Wilson, James F (author)
Illig, Thomas (author)
Froguel, Philippe (author)
van Duijn, Cornelia M (author)
Stefansson, Kari (author)
Altshuler, David (author)
Boehnke, Michael (author)
McCarthy, Mark I (author)
Soranzo, Nicole (author)
Wheeler, Eleanor (author)
Glazer, Nicole L (author)
Bouatia-Naji, Nabila (author)
Mägi, Reedik (author)
Randall, Joshua (author)
Johnson, Toby (author)
Elliott, Paul (author)
Rybin, Denis (author)
Henneman, Peter (author)
Dehghan, Abbas (author)
Hottenga, Jouke Jan (author)
Song, Kijoung (author)
Goel, Anuj (author)
Egan, Josephine M (author)
Lajunen, Taina (author)
Doney, Alex (author)
Kanoni, Stavroula (author)
Cavalcanti-Proença, Christine (author)
Kumari, Meena (author)
Timpson, Nicholas J (author)
Zabena, Carina (author)
Ingelsson, Erik (author)
An, Ping (author)
O'Connell, Jeffrey (author)
Luan, Jian'an (author)
Elliott, Amanda (author)
McCarroll, Steven A (author)
Roccasecca, Rosa Maria (author)
Pattou, François (author)
Sethupathy, Praveen (author)
Ariyurek, Yavuz (author)
Barter, Philip (author)
Beilby, John P (author)
Ben-Shlomo, Yoav (author)
Bergmann, Sven (author)
Bochud, Murielle (author)
Bonnefond, Amélie (author)
Borch-Johnsen, Knut (author)
Böttcher, Yvonne (author)
Brunner, Eric (author)
Bumpstead, Suzannah J (author)
Chen, Yii-Der Ida (author)
Chines, Peter (author)
Clarke, Robert (author)
Coin, Lachlan J M (author)
Cooper, Matthew N (author)
Crisponi, Laura (author)
Day, Ian N M (author)
de Geus, Eco J C (author)
Delplanque, Jerome (author)
Fedson, Annette C (author)
Fischer-Rosinsky, Antje (author)
Forouhi, Nita G (author)
Frants, Rune (author)
Franzosi, Maria Grazia (author)
Galan, Pilar (author)
Goodarzi, Mark O (author)
Graessler, Jürgen (author)
Grundy, Scott (author)
Gwilliam, Rhian (author)
Hallmans, Göran (author)
Umeå universitet,Näringsforskning
Hammond, Naomi (author)
Han, Xijing (author)
Hartikainen, Anna-Liisa (author)
Hayward, Caroline (author)
Heath, Simon C (author)
Hercberg, Serge (author)
Hicks, Andrew A (author)
Hillman, David R (author)
Hingorani, Aroon D (author)
Hui, Jennie (author)
Hung, Joe (author)
Jula, Antti (author)
Kaakinen, Marika (author)
Kaprio, Jaakko (author)
Kesaniemi, Y Antero (author)
Kivimaki, Mika (author)
Knight, Beatrice (author)
Koskinen, Seppo (author)
Kovacs, Peter (author)
Kyvik, Kirsten Ohm (author)
Lathrop, G Mark (author)
Lawlor, Debbie A (author)
Le Bacquer, Olivier (author)
Lecoeur, Cécile (author)
Li, Yun (author)
Mahley, Robert (author)
Mangino, Massimo (author)
Manning, Alisa K (author)
Martínez-Larrad, María Teresa (author)
McAteer, Jarred B (author)
McPherson, Ruth (author)
Meisinger, Christa (author)
Melzer, David (author)
Meyre, David (author)
Mitchell, Braxton D (author)
Mukherjee, Sutapa (author)
Naitza, Silvia (author)
Neville, Matthew J (author)
Oostra, Ben A (author)
Orrù, Marco (author)
Pakyz, Ruth (author)
Paolisso, Giuseppe (author)
Pattaro, Cristian (author)
Pearson, Daniel (author)
Peden, John F (author)
Pedersen, Nancy L (author)
Perola, Markus (author)
Pfeiffer, Andreas F H (author)
Pichler, Irene (author)
Polasek, Ozren (author)
Posthuma, Danielle (author)
Potter, Simon C (author)
Pouta, Anneli (author)
Province, Michael A (author)
Psaty, Bruce M (author)
Rayner, Nigel W (author)
Rice, Kenneth (author)
Ripatti, Samuli (author)
Rivadeneira, Fernando (author)
Rolandsson, Olov (author)
Umeå universitet,Allmänmedicin
Sandbaek, Annelli (author)
Sandhu, Manjinder (author)
Sanna, Serena (author)
Sayer, Avan Aihie (author)
Scheet, Paul (author)
Seedorf, Udo (author)
Sharp, Stephen J (author)
Shields, Beverley (author)
Sijbrands, Eric J G (author)
Silveira, Angela (author)
Simpson, Laila (author)
Singleton, Andrew (author)
Smith, Nicholas L (author)
Sovio, Ulla (author)
Swift, Amy (author)
Syddall, Holly (author)
Syvänen, Ann-Christine (author)
Tanaka, Toshiko (author)
Tönjes, Anke (author)
Uitterlinden, André G (author)
van Dijk, Ko Willems (author)
Varma, Dhiraj (author)
Visvikis-Siest, Sophie (author)
Vitart, Veronique (author)
Vogelzangs, Nicole (author)
Waeber, Gérard (author)
Wagner, Peter J (author)
Walley, Andrew (author)
Ward, Kim L (author)
Watkins, Hugh (author)
Wild, Sarah H (author)
Willemsen, Gonneke (author)
Witteman, Jaqueline C M (author)
Yarnell, John W G (author)
Zelenika, Diana (author)
Zethelius, Björn (author)
Zhai, Guangju (author)
Zhao, Jing Hua (author)
Zillikens, M Carola (author)
Borecki, Ingrid B (author)
Loos, Ruth J F (author)
Meneton, Pierre (author)
Magnusson, Patrik K E (author)
Nathan, David M (author)
Williams, Gordon H (author)
Silander, Kaisa (author)
Salomaa, Veikko (author)
Smith, George Davey (author)
Bornstein, Stefan R (author)
Schwarz, Peter (author)
Spranger, Joachim (author)
Karpe, Fredrik (author)
Shuldiner, Alan R (author)
Cooper, Cyrus (author)
Dedoussis, George V (author)
Serrano-Ríos, Manuel (author)
Lind, Lars (author)
Palmer, Lyle J (author)
Franks, Paul W (author)
Umeå universitet,Medicin
Ebrahim, Shah (author)
Marmot, Michael (author)
Kao, W H Linda (author)
Pramstaller, Peter Paul (author)
Wright, Alan F (author)
Stumvoll, Michael (author)
Hamsten, Anders (author)
Buchanan, Thomas A (author)
Valle, Timo T (author)
Rotter, Jerome I (author)
Siscovick, David S (author)
Penninx, Brenda W J H (author)
Boomsma, Dorret I (author)
Deloukas, Panos (author)
Spector, Timothy D (author)
Ferrucci, Luigi (author)
Cao, Antonio (author)
Scuteri, Angelo (author)
Schlessinger, David (author)
Uda, Manuela (author)
Ruokonen, Aimo (author)
Jarvelin, Marjo-Riitta (author)
Waterworth, Dawn M (author)
Vollenweider, Peter (author)
Peltonen, Leena (author)
Mooser, Vincent (author)
Sladek, Robert (author)
show less...
 (creator_code:org_t)
2012-01-04
2012
English.
In: PloS one. - San Francisco : Public Library of Science (PLoS). - 1932-6203. ; 7:1, s. e29202-
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • We tested for interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, in up to 42569 participants. Both stratified genome-wide association (GWAS) analyses, in lean, overweight and obese individuals, and regression-type analyses in a non BMI-stratified overall sample were performed. The former did not uncover any novel locus with a major main effect, but supported modulation of effects for some known and potentially new urate loci. The latter highlighted a SNP at RBFOX3 reaching genome-wide significant level (effect size 0.014, 95% CI 0.008-0.02, P-inter= 2.6 x 10(-8)). Two top loci in interaction term analyses, RBFOX3 and ERO1LB-EDAR-ADD, also displayed suggestive differences in main effect size between the lean and obese strata. All top ranking loci for urate effect differences between BMI categories were novel and most had small magnitude but opposite direction effects between strata. They include the locus RBMS1-TANK (men, Pdifflean-overweight= 4.7 x 10(-8)), a region that has been associated with several obesity related traits, and TSPYL5 (men, Pdifflean-overweight= 9.1 x 10(-8)), regulating adipocytes-produced estradiol. The top-ranking known urate loci was ABCG2, the strongest known gout risk locus, with an effect halved in obese compared to lean men (Pdifflean-obese= 2 x 10(-4)). Finally, pathway analysis suggested a role for N-glycan biosynthesis as a prominent urate-associated pathway in the lean stratum. These results illustrate a potentially powerful way to monitor changes occurring in obesogenic environment.

Subject headings

Medical and Health Sciences  (hsv)
Basic Medicine  (hsv)
Medical Genetics  (hsv)
Medicin och hälsovetenskap  (hsv)
Medicinska grundvetenskaper  (hsv)
Medicinsk genetik  (hsv)

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By the author/editor
Palmer, Nicholet ...
McDonough, Caitr ...
Hicks, Pamela J
Roh, Bong H
Wing, Maria R
An, S Sandy
show more...
Hester, Jessica ...
Cooke, Jessica N
Bostrom, Meredit ...
Rudock, Megan E
Talbert, Matthew ...
Lewis, Joshua P
Ferrara, Assiami ...
Lu, Lingyi
Ziegler, Julie T
Sale, Michele M
Divers, Jasmin
Shriner, Daniel
Adeyemo, Adebowa ...
Rotimi, Charles ...
Ng, Maggie C Y
Langefeld, Carl ...
Freedman, Barry ...
Bowden, Donald W
Voight, Benjamin ...
Scott, Laura J
Steinthorsdottir ...
Morris, Andrew P
Dina, Christian
Welch, Ryan P
Zeggini, Elefthe ...
Huth, Cornelia
Aulchenko, Yurii ...
Thorleifsson, Gu ...
McCulloch, Laura ...
Ferreira, Teresa
Grallert, Harald
Amin, Najaf
Wu, Guanming
Willer, Cristen ...
Raychaudhuri, So ...
McCarroll, Steve ...
Langenberg, Clau ...
Hofmann, Oliver ...
Dupuis, Josée
Qi, Lu
Segrè, Ayellet V
van Hoek, Mandy
Navarro, Pau
Ardlie, Kristin
Balkau, Beverley
Benediktsson, Ra ...
Bennett, Amanda ...
Blagieva, Roza
Boerwinkle, Eric
Bonnycastle, Lor ...
Boström, Kristin ...
Bravenboer, Bert
Bumpstead, Suzan ...
Burtt, Noël P
Charpentier, Gui ...
Chines, Peter S
Cornelis, Marily ...
Couper, David J
Crawford, Gabe
Doney, Alex S F
Elliott, Katheri ...
Elliott, Amanda ...
Erdos, Michael R
Fox, Caroline S
Franklin, Christ ...
Ganser, Martha
Gieger, Christia ...
Grarup, Niels
Green, Todd
Griffin, Simon
Groves, Christop ...
Guiducci, Candac ...
Hadjadj, Samy
Hassanali, Neela ...
Herder, Christia ...
Isomaa, Bo
Jackson, Anne U
Johnson, Paul R ...
Jørgensen, Torbe ...
Kao, Wen H L
Klopp, Norman
Kong, Augustine
Kraft, Peter
Kuusisto, Johann ...
Lauritzen, Torst ...
Li, Man
Lieverse, Aloysi ...
Lindgren, Cecili ...
Lyssenko, Valeri ...
Marre, Michel
Meitinger, Thoma ...
Midthjell, Krist ...
Morken, Mario A
Narisu, Narisu
Nilsson, Peter
Owen, Katharine ...
Payne, Felicity
Perry, John R B
Petersen, Ann-Kr ...
Platou, Carl
Proença, Christi ...
Prokopenko, Inga
Rathmann, Wolfga ...
Rayner, N Willia ...
Robertson, Neil ...
Rocheleau, Ghisl ...
Roden, Michael
Sampson, Michael ...
Saxena, Richa
Shields, Beverle ...
Shrader, Peter
Sigurdsson, Gunn ...
Sparsø, Thomas
Strassburger, Kl ...
Stringham, Heath ...
Sun, Qi
Swift, Amy J
Thorand, Barbara
Tichet, Jean
Tuomi, Tiinamaij ...
van Dam, Rob M
van Haeften, Tim ...
van Herpt, Thijs
van Vliet-Ostapt ...
Walters, G Bragi
Weedon, Michael ...
Wijmenga, Cisca
Witteman, Jacque ...
Bergman, Richard ...
Cauchi, Stephane
Collins, Francis ...
Gloyn, Anna L
Gyllensten, Ulf
Hansen, Torben
Hide, Winston A
Hitman, Graham A
Hofman, Albert
Hunter, David J
Hveem, Kristian
Laakso, Markku
Mohlke, Karen L
Morris, Andrew D
Palmer, Colin N ...
Pramstaller, Pet ...
Rudan, Igor
Sijbrands, Eric
Stein, Lincoln D
Tuomilehto, Jaak ...
Uitterlinden, An ...
Walker, Mark
Wareham, Nichola ...
Watanabe, Richar ...
Abecasis, Goncal ...
Boehm, Bernhard ...
Campbell, Harry
Daly, Mark J
Hattersley, Andr ...
Hu, Frank B
Meigs, James B
Pankow, James S
Pedersen, Oluf
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Barroso, Inês
Florez, Jose C
Frayling, Timoth ...
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Illig, Thomas
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van Duijn, Corne ...
Stefansson, Kari
Altshuler, David
Boehnke, Michael
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Mägi, Reedik
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Goel, Anuj
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Sethupathy, Prav ...
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Bochud, Murielle
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Böttcher, Yvonne
Brunner, Eric
Bumpstead, Suzan ...
Chen, Yii-Der Id ...
Chines, Peter
Clarke, Robert
Coin, Lachlan J ...
Cooper, Matthew ...
Crisponi, Laura
Day, Ian N M
de Geus, Eco J C
Delplanque, Jero ...
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Fischer-Rosinsky ...
Forouhi, Nita G
Frants, Rune
Franzosi, Maria ...
Galan, Pilar
Goodarzi, Mark O
Graessler, Jürge ...
Grundy, Scott
Gwilliam, Rhian
Hallmans, Göran
Hammond, Naomi
Han, Xijing
Hartikainen, Ann ...
Hayward, Carolin ...
Heath, Simon C
Hercberg, Serge
Hicks, Andrew A
Hillman, David R
Hingorani, Aroon ...
Hui, Jennie
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Jula, Antti
Kaakinen, Marika
Kaprio, Jaakko
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Knight, Beatrice
Koskinen, Seppo
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Lathrop, G Mark
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Le Bacquer, Oliv ...
Lecoeur, Cécile
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Pakyz, Ruth
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Peden, John F
Pedersen, Nancy ...
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Pfeiffer, Andrea ...
Pichler, Irene
Polasek, Ozren
Posthuma, Daniel ...
Potter, Simon C
Pouta, Anneli
Province, Michae ...
Psaty, Bruce M
Rayner, Nigel W
Rice, Kenneth
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Rivadeneira, Fer ...
Rolandsson, Olov
Sandbaek, Annell ...
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Sanna, Serena
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Varma, Dhiraj
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Vogelzangs, Nico ...
Waeber, Gérard
Wagner, Peter J
Walley, Andrew
Ward, Kim L
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Wild, Sarah H
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Witteman, Jaquel ...
Yarnell, John W ...
Zelenika, Diana
Zethelius, Björn
Zhai, Guangju
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Loos, Ruth J F
Meneton, Pierre
Magnusson, Patri ...
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Lind, Lars
Palmer, Lyle J
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Articles in the publication
PloS one
By the university
Uppsala University
Umeå University

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