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  • Ekberg, Karin (author)

C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • American Diabetes Association,2007
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-16956
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-16956URI
  • https://doi.org/10.2337/dc06-1274DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:13911836URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-39412URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • OBJECTIVE - C-peptide replacement in animals results in amelioration of diabetes-induced functional and structural abnormalities in peripheral nerves. The present study was undertaken to examine whether C-peptide administration to patients with type 1 diabetes and peripheral neuropathy improves sensory nerve function. RESEARCH DESIGN AND METHODS - This was an exploratory, double-blinded, randomized, and placebo-controlled study with three study groups that was carried out at five centers in Sweden. C-peptide was given as a replacement dose (1.5 mg/day, divided into four subcutaneous doses) or a dose three times higher (4.5 mg/day) during 6 months. Neurological examination and neurophysiological measurements were performed before and after 6 months of treatment with C-peptide or placebo. RESULTS - The age of the 139 patients who completed the protocol was 44.2 ± 0.6 (mean ± SE) years and their duration of diabetes was 30.6 ± 0.8 years. Clinical neurological impairment (NIA) (score >7 points) of the lower extremities was present in 86% of the patients at baseline. Sensory nerve conduction velocity (SCV) was 2.6 ± 0.08 SD below body height-corrected normal values at baseline and improved similarly within the two C-peptide groups (P < 0.007). The number of patients responding with a SCV peak potential improvement >1.0 m/s was greater in C-peptide-treated patients than in those receiving placebo (P < 0.03). In the least severely affected patients (SCV < 2.5 SD below normal at baseline, n = 70) SCV improved by 1.0 m/s (P < 0.014 vs. placebo). NIA score and vibration perception both improved within the C-peptide-treated groups (P < 0.011 and P < 0.002). A1C levels (7.6 ± 0.1% at baseline) decreased slightly but similarly in C-peptide- and placebo-treated patients during the study. CONCLUSIONS - C-peptide treatment for 6 months improves sensory nerve function in early-stage type 1 diabetic neuropathy.

Subject headings and genre

  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Brismar, TomKarolinska Institutet (author)
  • Johansson, Bo-Lennart (author)
  • Lindström, Per (author)
  • Juntti-Berggren, LisaKarolinska Institutet (author)
  • Norrby, Anders (author)
  • Berne, ChristianUppsala universitet,Institutionen för medicinska vetenskaper,Endokrinologi, diabetes och metabolism(Swepub:uu)chber255 (author)
  • Arnqvist, Hans,1943-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Avdelningen för medicinsk cellbiologi,Endokrin- och magtarmmedicinska kliniken US(Swepub:liu)hanar64 (author)
  • Bolinder, JanKarolinska Institutet (author)
  • Wahren, JohnKarolinska Institutet (author)
  • Karolinska InstitutetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Related titles

  • In:Diabetes Care: American Diabetes Association30:1, s. 71-760149-59921935-5548

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