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Time-resolved prote...
Time-resolved protein nanocrystallography using an X-ray free-electron laser
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Aquila, Andrew (author)
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Hunter, Mark S. (author)
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Doak, R. Bruce (author)
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show more...
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Kirian, Richard A. (author)
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Fromme, Petra (author)
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White, Thomas A. (author)
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- Andreasson, Jakob (author)
- Uppsala universitet,Molekylär biofysik
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- Arnlund, David (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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Bajt, Saša (author)
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Barends, Thomas R. M. (author)
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Barthelmess, Miriam (author)
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Bogan, Michael J. (author)
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Bostedt, Christoph (author)
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Bottin, Hervé (author)
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Bozek, John D. (author)
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- Caleman, Carl (author)
- Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Molekylär biofysik
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Coppola, Nicola (author)
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- Davidsson, Jan (author)
- Uppsala universitet,Fysikalisk kemi
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DePonte, Daniel P. (author)
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Elser, Veit (author)
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Epp, Sascha W. (author)
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Erk, Benjamin (author)
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Fleckenstein, Holger (author)
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Foucar, Lutz (author)
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Frank, Matthias (author)
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Fromme, Raimund (author)
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Graafsma, Heinz (author)
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Grotjohann, Ingo (author)
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Gumprecht, Lars (author)
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- Hajdu, Janos (author)
- Uppsala universitet,Molekylär biofysik
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Hampton, Christina Y. (author)
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Hartmann, Andreas (author)
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Hartmann, Robert (author)
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Hau-Riege, Stefan (author)
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Hauser, Günter (author)
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Hirsemann, Helmut (author)
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Holl, Peter (author)
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Holton, James M. (author)
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Hömke, André (author)
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Johansson, Linda (author)
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Kimmel, Nils (author)
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Kassemeyer, Stephan (author)
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Krasniqi, Faton (author)
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Kühnel, Kai-Uwe (author)
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Liang, Mengning (author)
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Lomb, Lukas (author)
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- Malmerberg, Erik, 1980 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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Marchesini, Stefano (author)
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Martin, Andrew V. (author)
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- Maia, Filipe R.N.C. (author)
- Gothenburg University,Göteborgs universitet,Uppsala universitet,Molekylär biofysik,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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- Seibert, M. Marvin (author)
- Uppsala universitet,Molekylär biofysik
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Nass, Karol (author)
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Reich, Christian (author)
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Neutze, Richard (author)
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Rolles, Daniel (author)
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Rudek, Benedikt (author)
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Rudenko, Artem (author)
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Schlichting, Ilme (author)
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Schmidt, Carlo (author)
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Schmidt, Kevin E. (author)
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Schulz, Joachim (author)
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- Seibert, M. Marvin (author)
- Uppsala universitet,Molekylär biofysik
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Soltau, Heike (author)
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Shoeman, Robert L. (author)
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Sierra, Raymond (author)
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Starodub, Dmitri (author)
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Stellato, Francesco (author)
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Stern, Stephan (author)
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Strüder, Lothar (author)
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- Timneanu, Nicusor (author)
- Uppsala universitet,Molekylär biofysik
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Ullrich, Joachim (author)
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Wang, Xiaoyu (author)
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Williams, Garth J. (author)
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Weidenspointner, Georg (author)
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Weierstall, Uwe (author)
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Wunderer, Cornelia (author)
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Barty, Anton (author)
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Spence, John C. H. (author)
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Chapman, Henry N. (author)
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(creator_code:org_t)
- 2012
- 2012
- English.
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In: Optics Express. - 1094-4087. ; 20:3, s. 2706-2716
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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Abstract
Subject headings
Close
- We demonstrate the use of an X-ray free electron laser synchronized with an optical pump laser to obtain X-ray diffraction snapshots from the photoactivated states of large membrane protein complexes in the form of nanocrystals flowing in a liquid jet. Light-induced changes of Photosystem I-Ferredoxin co-crystals were observed at time delays of 5 to 10 µs after excitation. The result correlates with the microsecond kinetics of electron transfer from Photosystem I to ferredoxin. The undocking process that follows the electron transfer leads to large rearrangements in the crystals that will terminally lead to the disintegration of the crystals. We describe the experimental setup and obtain the first time-resolved femtosecond serial X-ray crystallography results from an irreversible photo-chemical reaction at the Linac Coherent Light Source. This technique opens the door to time-resolved structural studies of reaction dynamics in biological systems.
Subject headings
- NATURVETENSKAP -- Biologi -- Strukturbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Structural Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Laser-induced chemistry
- Ultrafast lasers
- Medical optics and biotechnology
- Ultrafast technology
- X-ray imaging
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Aquila, Andrew
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Hunter, Mark S.
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Doak, R. Bruce
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Kirian, Richard ...
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Fromme, Petra
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White, Thomas A.
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show more...
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Andreasson, Jako ...
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Arnlund, David
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Bajt, Saša
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Barends, Thomas ...
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Barthelmess, Mir ...
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Bogan, Michael J ...
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Bostedt, Christo ...
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Bottin, Hervé
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Bozek, John D.
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Caleman, Carl
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Coppola, Nicola
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Davidsson, Jan
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DePonte, Daniel ...
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Elser, Veit
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Epp, Sascha W.
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Erk, Benjamin
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Fleckenstein, Ho ...
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Foucar, Lutz
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Frank, Matthias
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Fromme, Raimund
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Graafsma, Heinz
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Grotjohann, Ingo
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Gumprecht, Lars
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Hajdu, Janos
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Hampton, Christi ...
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Hartmann, Andrea ...
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Hartmann, Robert
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Hau-Riege, Stefa ...
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Hauser, Günter
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Hirsemann, Helmu ...
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Holl, Peter
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Holton, James M.
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Hömke, André
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Johansson, Linda
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Kimmel, Nils
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Kassemeyer, Step ...
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Krasniqi, Faton
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Kühnel, Kai-Uwe
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Liang, Mengning
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Lomb, Lukas
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Malmerberg, Erik ...
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Marchesini, Stef ...
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Martin, Andrew V ...
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Maia, Filipe R.N ...
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Seibert, M. Marv ...
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Nass, Karol
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Reich, Christian
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Neutze, Richard
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Rolles, Daniel
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Rudek, Benedikt
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Rudenko, Artem
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Schlichting, Ilm ...
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Schmidt, Carlo
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Schmidt, Kevin E ...
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Schulz, Joachim
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Soltau, Heike
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Shoeman, Robert ...
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Sierra, Raymond
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Starodub, Dmitri
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Stellato, France ...
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Stern, Stephan
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Strüder, Lothar
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Timneanu, Nicuso ...
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Ullrich, Joachim
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Wang, Xiaoyu
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Williams, Garth ...
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Weidenspointner, ...
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Weierstall, Uwe
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Wunderer, Cornel ...
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Barty, Anton
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Spence, John C. ...
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Chapman, Henry N ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Structural Biolo ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biophysics
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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Optics Express
- By the university
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Uppsala University
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University of Gothenburg