Sökning: WFRF:(Alvi Muhammad Rouf) >
Scope and Limitatio...
Scope and Limitations of an Acid Catalyzed Protocol for Hypersilyl Protection of Alcohols
-
- Alvi, Muhammad Rouf (författare)
- Uppsala universitet,Institutionen för kemi - BMC
-
- Anas, Saithalavi (författare)
- Uppsala universitet,Institutionen för kemi - BMC
-
- Emanuelsson, Rikard (författare)
- Uppsala universitet,Institutionen för kemi - BMC
-
visa fler...
-
- Lozinski, Kaitlin (författare)
- Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC) and Department of Chemistry, University of Richmond, UR 1099, 28 Westhampton Way, VA 23173, USA,Department of Chemistry-BMC
-
- Ottosson, Henrik (författare)
- Uppsala universitet,Institutionen för kemi - BMC
-
visa färre...
-
(creator_code:org_t)
- Engelska.
- Relaterad länk:
-
https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- A highly efficient and convenient triflic acid (TfOH) catalyzed protocol for the protection of various functionalized alcohols in CH2Cl2 at ambient temperature using tris(trimethylsilyl)silyl-N,N-dimethyl-methaneamide (hypersilylamide) 1 as the protecting reagent is developed. Herein, results on the scope and limitations of this protocol for a number of functionalized alcohols are presented. This method was found to be effective for the selective protection of less hindered OH groups in different classes of diols containing both pri/tert, sec/tert, or aromatic/aliphatic hydroxyl groups. In general, our protocol exhibited excellent functional group tolerance in the protection of alcohols containing alkoxy, keto, amino, as well as halo substituents in good to excellent yields.
Ämnesord
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Publikations- och innehållstyp
- vet (ämneskategori)
- ovr (ämneskategori)