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Human kininogen fro...
Human kininogen from Cohns Fraction IV : comparisons of antigenicity and multiple forms
- Article/chapterEnglish1979
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LIBRIS-ID:oai:DiVA.org:uu-169932
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-169932URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Kininogen was isolated from Cohns fraction IV by DEAE-chromatography, gel filtration and ammonium sulphate precipitation. Immunologically pure kininogen was prepared by removal of protein impurities using specific immunoadsorbents with Sepharose-bound antibody. Anti-kininogen serum was raised in rabbits against the pure antigen. Comparison with anti-kininogen sera prepared with the biologically active LMW antigen from whole plasma suggested antigenic identity by double immunodiffusion analysis. The Cohn-kininogen was shown to contain mainly two components (85%) in about equal amounts focusing with peaks at pI 4.2 (42%) and pI 4.3 (43%). These represent apparently structurally altered forms of the native plasma kininogen focusing at pI 4.5-4.6 (54%), which occurred as a minor component (13%).
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Syvanen, Ann-Christine
(author)
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Karkkainen, T
(author)
Related titles
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In:Advances in Experimental Medicine and Biology120B, s. 173-1830065-25982214-8019
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