Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11-labeled Pittsburgh Compound B.

OBJECTIVE: To compare carbon 11-labeled Pittsburgh Compound B ([11C]PiB) positron emission tomography (PET) findings in patients with and without Alzheimer disease lesions in frontal cortical biopsy specimens.DESIGN: Cross-sectional study of [11C]PiB PET findings in patients with or without beta-amyloid (Abeta) aggregates in frontal cortical biopsy specimens.SETTING: Two university hospitals in Finland. Patients Ten patients who had undergone intraventricular pressure monitoring with a frontal cortical biopsy (evaluated for Abeta aggregates and hyperphosphorylated tau) for suspected normal-pressure hydrocephalus.INTERVENTIONS: [11C]PiB PET and evaluation for cognitive impairment using a battery of neuropsychological tests.MAIN OUTCOME MEASURES: Immunohistochemical evaluation for Abeta aggregates and hyperphosphorylated tau in the frontal cortical biopsy specimen and [11C]PiB PET.RESULTS: In patients with Abeta aggregates in the frontal cortical biopsy specimen, PET imaging revealed higher [11C]PiB uptake (P < .05) in the frontal, parietal, and lateral temporal cortices and in the striatum as compared with the patients without frontal Abeta deposits.CONCLUSIONS: Our study supports the use of noninvasive [11C]PiB PET in the assessment of Abeta deposition in the brain. Large prospective studies are required to verify whether [11C]PiB PET will be a diagnostic aid, particularly in early Alzheimer disease.

Alafuzoff, IrinaDepartment of Neuroscience and Neurology, University of Kuopio Finland (author)
Aalto, Sargo (author)
Suotunen, Timo (author)
Savolainen, Sakari (author)
Någren, Kjell (author)
Tapiola, Tero (author)
Pirttilä, Tuula (author)
Rinne, Jaakko (author)
Jääskeläinen, Juha E (author)
Soininen, Hilkka (author)
Rinne, Juha O (author)
Department of Neuroscience and Neurology, University of Kuopio Finland (creator_code:org_t)

In:Archives of Neurology: American Medical Association (AMA)65:10, s. 1304-90003-99421538-3687

By the author/editor: Leinonen, Ville; Alafuzoff, Irina; Aalto, Sargo; Suotunen, Timo; Savolainen, Saka ...; Någren, Kjell; show more...; Tapiola, Tero; Pirttilä, Tuula; Rinne, Jaakko; Jääskeläinen, Ju ...; Soininen, Hilkka; Rinne, Juha O; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Clinical Laborat ...

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