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Staging of neurofib...
Staging of neurofibrillary pathology in Alzheimer's disease : a study of the BrainNet Europe Consortium.
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- Alafuzoff, Irina (author)
- Department of Neuroscience and Neurology, University of Kuopio Finland
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Arzberger, Thomas (author)
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Al-Sarraj, Safa (author)
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Bodi, Istvan (author)
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- Bogdanovic, Nenad (author)
- Karolinska Institutet
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Braak, Heiko (author)
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Bugiani, Orso (author)
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Del-Tredici, Kelly (author)
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Ferrer, Isidro (author)
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Gelpi, Ellen (author)
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Giaccone, Giorgio (author)
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Graeber, Manuel B (author)
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Ince, Paul (author)
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Kamphorst, Wouter (author)
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King, Andrew (author)
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Korkolopoulou, Penelope (author)
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Kovács, Gábor G (author)
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Larionov, Sergey (author)
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Meyronet, David (author)
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Monoranu, Camelia (author)
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Parchi, Piero (author)
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Patsouris, Efstratios (author)
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Roggendorf, Wolfgang (author)
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Seilhean, Danielle (author)
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Tagliavini, Fabrizio (author)
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Stadelmann, Christine (author)
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Streichenberger, Nathalie (author)
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Thal, Dietmar R (author)
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Wharton, Stephen B (author)
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Kretzschmar, Hans (author)
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(creator_code:org_t)
- 2008-03-27
- 2008
- English.
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In: Brain Pathology. - : Wiley. - 1015-6305 .- 1750-3639. ; 18:4, s. 484-96
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- It has been recognized that molecular classifications will form the basis for neuropathological diagnostic work in the future. Consequently, in order to reach a diagnosis of Alzheimer's disease (AD), the presence of hyperphosphorylated tau (HP-tau) and beta-amyloid protein in brain tissue must be unequivocal. In addition, the stepwise progression of pathology needs to be assessed. This paper deals exclusively with the regional assessment of AD-related HP-tau pathology. The objective was to provide straightforward instructions to aid in the assessment of AD-related immunohistochemically (IHC) detected HP-tau pathology and to test the concordance of assessments made by 25 independent evaluators. The assessment of progression in 7-microm-thick sections was based on assessment of IHC labeled HP-tau immunoreactive neuropil threads (NTs). Our results indicate that good agreement can be reached when the lesions are substantial, i.e., the lesions have reached isocortical structures (stage V-VI absolute agreement 91%), whereas when only mild subtle lesions were present the agreement was poorer (I-II absolute agreement 50%). Thus, in a research setting when the extent of lesions is mild, it is strongly recommended that the assessment of lesions should be carried out by at least two independent observers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- Pathology
- Patologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Alafuzoff, Irina
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Arzberger, Thoma ...
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Al-Sarraj, Safa
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Bodi, Istvan
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Bogdanovic, Nena ...
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Braak, Heiko
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show more...
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Bugiani, Orso
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Del-Tredici, Kel ...
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Ferrer, Isidro
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Gelpi, Ellen
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Giaccone, Giorgi ...
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Graeber, Manuel ...
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Ince, Paul
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Kamphorst, Woute ...
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King, Andrew
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Korkolopoulou, P ...
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Kovács, Gábor G
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Larionov, Sergey
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Meyronet, David
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Monoranu, Cameli ...
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Parchi, Piero
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Patsouris, Efstr ...
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Roggendorf, Wolf ...
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Seilhean, Daniel ...
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Tagliavini, Fabr ...
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Stadelmann, Chri ...
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Streichenberger, ...
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Thal, Dietmar R
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Wharton, Stephen ...
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Kretzschmar, Han ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
- Articles in the publication
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Brain Pathology
- By the university
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Uppsala University
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Karolinska Institutet