Blood-cerebrospinal fluid barrier in hyperthermia

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: L773:0079 6123 OR L773:1875 7855 OR L773:9780444642608 > Blood-cerebrospinal...

Sharma, Hari ShankerUppsala universitet,Institutionen för kirurgiska vetenskaper,Anaesthesiology and Intensive Care (författare)

Blood-cerebrospinal fluid barrier in hyperthermia

Artikel/kapitelEngelska2007

Förlag, utgivningsår, omfång ...

2007
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:uu-17228
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-17228URI
https://doi.org/10.1016/S0079-6123(06)62023-2DOI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:ref swepub-contenttype
Ämneskategori:for swepub-publicationtype

Anmärkningar

The blood-CSF barrier (BCSFB) in choroid plexus works with the blood-brain barrier (BBB) in cerebral capillaries to stabilize the fluid environment of neurons. Dysfunction of either transport interface, i.e., BCSFB or BBB, causes augmented fluxes of ions, water and proteins into the CNS. These barrier disruptions lead to problems with edema and other compromised homeostatic mechanisms. Hyperthermic effects on BCSFB permeability and transport are not as well known as for BBB. However, it is becoming increasingly appreciated that elevated prostaglandin synthesis from fever/heat activation of cyclooxygenases (COXs) in the BCSFB promotes water and ion transfer from plasma to the ventricles; this harmful fluid movement into the CSF-brain interior can be attenuated by agents that inhibit the COXs. Moreover, new functional data from our laboratory animal model indicate that the BCSFB (choroidal epithelium) and the CSF-bordering ependymal cells are vulnerable to whole body hyperthermia (WBH). This is evidenced from the fact that rats subjected to 4h of heat stress (38 degrees C) showed a significant increase in the translocation of Evans blue and (131)Iodine from plasma to cisternal CSF, and manifested blue staining of the dorsal surface of the hippocampus and caudate nucleus. Degeneration of choroidal epithelial cells and underlying ependyma, a dilated ventricular space and damage to the underlying neuropil were frequent. A disrupted BCSFB is associated with a marked increase in edema formation in the hippocampus, caudate nucleus, thalamus and hypothalamus. Taken together, these findings suggest that the breaching of the BCSFB in hyperthermia significantly contributes to cell and tissue injuries in the CNS.

Ämnesord och genrebeteckningar

131Iodine transport into CSF
blood-brain barrier
blood-cerebrospinal fluid barrier
brain edema
choroid plexus
cyclooxygenases
Evans blue
fever
heat stress
neurodegeneration
prostaglandins
pyrogens
whole body hyperthermia
MEDICINE
MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

Johanson, Conrad Earl (författare)
Uppsala universitetInstitutionen för kirurgiska vetenskaper (creator_code:org_t)

Sammanhörande titlar

Ingår i:Progress in Brain Research162, s. 459-4780079-61231875-7855

Internetlänk

Hitta via bibliotek

Progress in Brain Research (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Sharma, Hari Sha ...; Johanson, Conrad ...

Artiklar i publikationen: Progress in Brai ...

Av lärosätet: Uppsala universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se