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Prognostic superior...
Prognostic superiority of daytime ambulatory over conventional blood pressure in four populations : a meta-analysis of 7,030 individuals
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Hansen, Tine W. (författare)
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Kikuya, Masahiro (författare)
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Thijs, Lutgarde (författare)
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- Björklund-Bodegård, Kristina (författare)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap
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Kuznetsova, Tatiana (författare)
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Ohkubo, Takayoshi (författare)
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Richart, Tom (författare)
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Torp-Pedersen, Christian (författare)
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- Lind, Lars (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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Jeppesen, Jørgen (författare)
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Ibsen, Hans (författare)
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Imai, Yutaka (författare)
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Staessen, Jan A. (författare)
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(creator_code:org_t)
- 2007
- 2007
- Engelska.
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Ingår i: Journal of Hypertension. - 0263-6352 .- 1473-5598. ; 25:8, s. 1554-1564
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective To investigate the multivariate-adjusted predictive value of systolic and diastolic blood pressures on conventional (CBP) and daytime (10-20h) ambulatory (ABP) measurement. Methods We randomly recruited 7030 subjects (mean age 56.2 years; 44.8% women) from populations in Belgium, Denmark, Japan and Sweden. We constructed the International Database on Ambulatory blood pressure and Cardiovascular Outcomes. Results During follow-up (median = 9.5 years), 932 subjects died. Neither CBP nor ABP predicted total mortality, of which 60.9% was due to noncardiovascular causes. The incidence of fatal combined with nonfatal cardiovascular events amounted to 863 (228 deaths, 326 strokes and 309 cardiac events). In multivariate-adjusted continuous analyses, both CBP and ABP predicted cardiovascular, cerebrovascular, cardiac and coronary events. However, in fully-adjusted models, including both CBP and ABP, CBP lost its predictive value (P>0.052), whereas systolic and diastolic ABP retained their prognostic significance (P< 0.007) with the exception of diastolic ABP as predictor of cardiac and coronary events (P>0.21). In adjusted categorical analyses, normotension was the referent group (CBP<140/90 mmHg and ABP<135/ 85 mmHg). Adjusted hazard ratios for all cardiovascular events were 1.22 [95% confidence interval (Cl) = 0.96-1.53; P=0.09] for white-coat hypertension (≥140/90 and <135/85 mmHg); 1.62 (95% Cl = 1.35-1.96; P< 0.0001) for masked hypertension (<140/90 and ≥ 135/85 mmHg); and 1.80 (95% Cl = 1.59-2.03; P<0.0001) for sustained hypertension (≥140/90 and ≥135/85 mmHg). Conclusions ABP is superior to CBP in predicting cardiovascular events, but not total and noncardiovascular mortality. Cardiovascular risk gradually increases from normotension over white-coat and masked hypertension to sustained hypertension.
Nyckelord
- Ambulatory blood pressure
- Cardiovascular disease
- Epidemiology
- Masked hypertension
- White-coat hypertension
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Hansen, Tine W.
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Kikuya, Masahiro
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Thijs, Lutgarde
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Björklund-Bodegå ...
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Kuznetsova, Tati ...
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Ohkubo, Takayosh ...
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visa fler...
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Richart, Tom
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Torp-Pedersen, C ...
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Lind, Lars
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Jeppesen, Jørgen
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Ibsen, Hans
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Imai, Yutaka
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Staessen, Jan A.
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visa färre...
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Journal of Hyper ...
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Uppsala universitet