Dietary Cadmium Exposure and Risk of Postmenopausal Breast Cancer: A Population-Based Prospective Cohort Study

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Julin, BettinaKarolinska Institutet (author)

Dietary Cadmium Exposure and Risk of Postmenopausal Breast Cancer : A Population-Based Prospective Cohort Study

Article/chapterEnglish2012

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2012
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LIBRIS-ID:oai:DiVA.org:uu-172826
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-172826URI
https://doi.org/10.1158/0008-5472.CAN-11-0735DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:124263272URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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The ubiquitous food contaminant cadmium has features of an estrogen mimetic that may promote the development of estrogen-dependent malignancies, such as breast cancer. However, no prospective studies of cadmium exposure and breast cancer risk have been reported. , We examined the association between dietary cadmium exposure (at baseline, 1987) and the risk of overall and estrogen receptor (ER)-defined (ER+ or ER-) breast cancer within a population-based prospective cohort of 55,987 postmenopausal women. During an average of 12.2 years of follow-up, 2,112 incident cases of invasive breast cancer were ascertained (1,626 ER+ and 290 ER-). After adjusting for confounders, including consumption of whole grains and vegetables (which account for 40% of the dietary exposure, but also contain putative anticarcinogenic phytochemicals), dietary cadmium intake was positively associated with overall breast cancer tumors, comparing the highest tertile with the lowest [rate ratio (RR), 1.21; 95% confidence interval (CI), 1.07-1.36; P-trend = 0.02]. Among lean and normal weight women, statistically significant associations were observed for all tumors (RR, 1.27; 95% CI, 1.07-1.50) and for ER+ tumors (RR, 125; 95% CI, 1.03-1.52) and similar, but not statistically significant associations were found for ER- tumors (RR, 1.22; 95% CI, 0.76-1.93). The risk of breast cancer increased with increasing cadmium exposure similarly within each textile of whole grain/vegetable consumption and decreased with increasing consumption of whole grain/vegetables within each tertile of cadmium exposure (P-interaction = 0.73). Overall, these results suggest a role for dietary cadmium in postmenopausal breast cancer development.

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Wolk, AlicjaKarolinska Institutet (author)
Bergkvist, LeifUppsala universitet,Centrum för klinisk forskning, Västerås(Swepub:uu)leber451 (author)
Bottai, MatteoKarolinska Institutet (author)
Akesson, AgnetaKarolinska Institutet (author)
Karolinska InstitutetCentrum för klinisk forskning, Västerås (creator_code:org_t)

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In:Cancer Research72:6, s. 1459-14660008-54721538-7445

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By the author/editor: Julin, Bettina; Wolk, Alicja; Bergkvist, Leif; Bottai, Matteo; Akesson, Agneta

Articles in the publication: Cancer Research

By the university: Uppsala University; Karolinska Institutet

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