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Per- and polyfluoro...
Per- and polyfluoroalkyl substances enhance Staphylococcus aureus pathogenicity and impair host immune response
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- Mangu, Jagadish, 1986- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,The Life Science Centre-Biology
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- Stylianou, Marios (author)
- School of Science and Technology, Örebro University, Örebro, Sweden,The Life Science Centre-Biology
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- Olsson, Per-Erik, 1957- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,The Life Science Centre-Biology
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- Jass, Jana, 1963- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,The Life Science Centre-Biology
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(creator_code:org_t)
- Springer, 2022
- 2022
- English.
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In: Environmental Pollution. - : Springer. - 0269-7491 .- 1873-6424. ; 314
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Per- and Poly-fluoroalkyl substances (PFAS) are one of the major persistent environmental contaminants. Epidemiological studies have linked PFAS exposures to altered immunity and increased occurrence of infections in children. However, the mechanisms leading to immune susceptibility to bacterial infections remains unclear. To elucidate the mechanism, transcriptional alteration in the Caenorhabditis elegans model caused by a PFAS contaminated environmental water and two reconstituted PFAS solutions were evaluated using RNA-sequencing. PFAS affected the expression of several genes involved in C. elegans immune surveillance to Gram-positive bacteria (cpr-2, tag-38, spp-1, spp-5, clec-7, clec-172). The combined exposure to PFAS and Staphylococcus aureus significantly reduced C. elegans survival and increased intestinal membrane permeability. Furthermore, the growth of S. aureus in the presence of PFAS increased the expression of virulence genes, specifically, the virulence gene regulator saeR and α-hemolysin, hla, which resulted in increased hemolytic activity. The present study demonstrated that PFAS exposure not only increased C. elegans susceptibility to pathogens by reducing host immunity and increasing intestinal membrane permeability, but also increased bacteria virulence. This presents a broader implication for humans and other animals, where environmental contaminants simultaneously reduce host resilience, while, increasing microbial pathogenicity.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- C. elegans
- Hemolysin
- Immune suppression
- PFAS
- S. aureus
Publication and Content Type
- ref (subject category)
- art (subject category)
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