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  • Fridberg, MarieLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine,Department of Tumor Biology, Lund University, Malmö University Hospital, Malmö, Sweden (author)

Protein expression and cellular localization in two prognostic subgroups of diffuse large B-cell lymphoma : higher expression of ZAP70 and PKC-beta II in the non-germinal center group and poor survival in patients deficient in nuclear PTEN

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • 2009-07
  • Informa UK Limited,2007
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-17451
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-17451URI
  • https://doi.org/10.1080/10428190701636443DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-177652URI
  • https://lup.lub.lu.se/record/1138039URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-4801URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-48255URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Patients diagnosed with diffuse large B-cell lymphoma (DLBCL) show varying responses to conventional therapy, and this might be contributed to the differentiation stage of the tumor B-cells. The aim of the current study was to evaluate a panel of kinases (ZAP70, PKC-β I and II and phosphorylated PKB/Akt) and phosphatases (PTEN, SHP1 and SHP2) known to be frequently deregulated in lymphoid malignancies. De novo DLBCL cases were divided into two subgroups, the germinal center (GC) group (14/28) and the non-germinal center (non-GC) or activated B-cell (ABC) group (14/28). ZAP70 and PKC-β II were expressed in a significantly higher percentage of tumor cells in the clinically more aggressive non-GC group compared with the prognostically favourable GC group. Also, the subcellular localization of PKC-β I and II differed in DLBCL cells, with the PKC-β I isoform being expressed in both the cytoplasm and nucleus, while PKC-β II was found exclusively in the cytoplasm. Loss of nuclear PTEN correlated with poor survival in cases from both subgroups. In addition, five cell lines of DLBCL origin were analyzed for protein expression and for mRNA levels of PTEN and SHP1. For the first time, we show that ZAP70 is expressed in a higher percentage of tumor cells in the aggressive non-GC subgroup of DLBCL and that PKC-β I and II are differently distributed in the two prognostic subgroups of de novo DLBCL.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Servin, AnnaDepartment of Tumor Biology, Lund University, Malmö University Hospital, Malmö, Sweden (author)
  • Anagnostaki, LolaDepartment of Pathology, Lund University, Malmö University Hospital, Malmö, Sweden (author)
  • Linderoth, JohanLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Oncology, Lund University, Lund, Sweden(Swepub:lu)onk-jli (author)
  • Berglund, MattiasUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Lymfomgruppen,Department of Oncology, Radiology and Clinical Immunology, Section of Oncology, Uppsala University, Uppsala, Sweden(Swepub:uu)mattiber (author)
  • Söderberg, OlaUppsala universitet,Institutionen för genetik och patologi,Söderberg, O., Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden(Swepub:uu)olasoder (author)
  • Enblad, GunillaUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Lymfomgruppen,Department of Oncology, Radiology and Clinical Immunology, Section of Oncology, Uppsala University, Uppsala, Sweden(Swepub:uu)gunienbl (author)
  • Rosén, AndersLinköpings universitet,Hälsouniversitetet,Cellbiologi(Swepub:liu)andro72 (author)
  • Mustelin, TomasLaboratory of Signal Transduction, The Burnham Institute, La Jolla, CA, United States (author)
  • Jerkeman, MatsLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Oncology, Lund University, Lund, Sweden(Swepub:lu)onk-mje (author)
  • Persson, Jenny L.,ProfessorLund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups,Department of Pathology, Lund University, Malmö University Hospital, Malmö, Sweden(Swepub:lu)medk-jpe (author)
  • Gjörloff Wingren, AnetteMalmö högskola,Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine,Fakulteten för hälsa och samhälle (HS),Department of Tumor Biology, Lund University, Malmö University Hospital, Malmö, Sweden(Swepub:mau)hsangj (author)
  • Institutionen för translationell medicinMedicinska fakulteten (creator_code:org_t)

Related titles

  • In:Leukemia and Lymphoma: Informa UK Limited48:11, s. 2221-22321042-81941029-2403

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