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Genome-Wide Associa...
Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function
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Pattaro, Cristian (author)
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Koettgen, Anna (author)
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Teumer, Alexander (author)
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show more...
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Garnaas, Maija (author)
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Boeger, Carsten A. (author)
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Fuchsberger, Christian (author)
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Olden, Matthias (author)
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Chen, Ming-Huei (author)
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Tin, Adrienne (author)
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Taliun, Daniel (author)
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Li, Man (author)
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Gao, Xiaoyi (author)
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Gorski, Mathias (author)
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Yang, Qiong (author)
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Hundertmark, Claudia (author)
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Foster, Meredith C. (author)
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O'Seaghdha, Conall M. (author)
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Glazer, Nicole (author)
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Isaacs, Aaron (author)
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Liu, Ching-Ti (author)
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Smith, Albert V. (author)
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O'Connell, Jeffrey R. (author)
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Struchalin, Maksim (author)
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Tanaka, Toshiko (author)
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Li, Guo (author)
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Johnson, Andrew D. (author)
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Gierman, Hinco J. (author)
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Feitosa, Mary (author)
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Hwang, Shih-Jen (author)
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Atkinson, Elizabeth J. (author)
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Lohman, Kurt (author)
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Cornelis, Marilyn C. (author)
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- Johansson, Åsa (author)
- Uppsala universitet,Genomik,Gyllensten
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Toenjes, Anke (author)
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Dehghan, Abbas (author)
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Chouraki, Vincent (author)
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Holliday, Elizabeth G. (author)
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Sorice, Rossella (author)
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Kutalik, Zoltan (author)
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Lehtimaeki, Terho (author)
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Esko, Tonu (author)
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Deshmukh, Harshal (author)
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Ulivi, Sheila (author)
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Chu, Audrey Y. (author)
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Murgia, Federico (author)
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Trompet, Stella (author)
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Imboden, Medea (author)
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Kollerits, Barbara (author)
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Pistis, Giorgio (author)
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Harris, Tamara B. (author)
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Launer, Lenore J. (author)
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Aspelund, Thor (author)
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Eiriksdottir, Gudny (author)
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Mitchell, Braxton D. (author)
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Boerwinkle, Eric (author)
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Schmidt, Helena (author)
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Cavalieri, Margherita (author)
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Rao, Madhumathi (author)
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Hu, Frank B. (author)
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Demirkan, Ayse (author)
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Oostra, Ben A. (author)
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de Andrade, Mariza (author)
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Turner, Stephen T. (author)
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Ding, Jingzhong (author)
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Andrews, Jeanette S. (author)
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Freedman, Barry I. (author)
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Koenig, Wolfgang (author)
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Illig, Thomas (author)
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Doering, Angela (author)
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Wichmann, H. -Erich (author)
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Kolcic, Ivana (author)
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Zemunik, Tatijana (author)
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Boban, Mladen (author)
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Minelli, Cosetta (author)
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Wheeler, Heather E. (author)
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- Igl, Wilmar (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Zaboli, Ghazal (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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Wild, Sarah H. (author)
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Wright, Alan F. (author)
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Campbell, Harry (author)
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Ellinghaus, David (author)
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Nothlings, Ute (author)
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Jacobs, Gunnar (author)
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Biffar, Reiner (author)
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Endlich, Karlhans (author)
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Ernst, Florian (author)
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Homuth, Georg (author)
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Kroemer, Heyo K. (author)
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Nauck, Matthias (author)
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Stracke, Sylvia (author)
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Voelker, Uwe (author)
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Voelzke, Henry (author)
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Kovacs, Peter (author)
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Stumvoll, Michael (author)
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Magi, Reedik (author)
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Hofman, Albert (author)
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Uitterlinden, Andre G. (author)
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Rivadeneira, Fernando (author)
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Aulchenko, Yurii S. (author)
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Polasek, Ozren (author)
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Hastie, Nick (author)
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Vitart, Veronique (author)
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Helmer, Catherine (author)
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Wang, Jie Jin (author)
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Ruggiero, Daniela (author)
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Bergmann, Sven (author)
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Kaehoenen, Mika (author)
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Viikari, Jorma (author)
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Nikopensius, Tiit (author)
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Province, Michael (author)
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Ketkar, Shamika (author)
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Colhoun, Helen (author)
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Doney, Alex (author)
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Robino, Antonietta (author)
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Giulianini, Franco (author)
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Kraemer, Bernhard K. (author)
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Portas, Laura (author)
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Ford, Ian (author)
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Buckley, Brendan M. (author)
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Adam, Martin (author)
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Thun, Gian-Andri (author)
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Paulweber, Bernhard (author)
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Haun, Margot (author)
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Sala, Cinzia (author)
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Metzger, Marie (author)
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Mitchell, Paul (author)
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Ciullo, Marina (author)
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Kim, Stuart K. (author)
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Vollenweider, Peter (author)
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Raitakari, Olli (author)
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Metspalu, Andres (author)
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Palmer, Colin (author)
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Gasparini, Paolo (author)
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Pirastu, Mario (author)
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Jukema, J. Wouter (author)
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Probst-Hensch, Nicole M. (author)
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Kronenberg, Florian (author)
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Toniolo, Daniela (author)
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Gudnason, Vilmundur (author)
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Shuldiner, Alan R. (author)
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Coresh, Josef (author)
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Schmidt, Reinhold (author)
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Ferrucci, Luigi (author)
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Siscovick, David S. (author)
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van Duijn, Cornelia M. (author)
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Borecki, Ingrid (author)
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Kardia, Sharon L. R. (author)
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Liu, Yongmei (author)
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Curhan, Gary C. (author)
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Rudan, Igor (author)
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- Gyllensten, Ulf (author)
- Uppsala universitet,Genomik,Gyllensten
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Wilson, James F. (author)
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Franke, Andre (author)
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Pramstaller, Peter P. (author)
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Rettig, Rainer (author)
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Prokopenko, Inga (author)
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Witteman, Jacqueline C. M. (author)
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Hayward, Caroline (author)
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Ridker, Paul (author)
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Parsa, Afshin (author)
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Bochud, Murielle (author)
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Heid, Iris M. (author)
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Goessling, Wolfram (author)
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Chasman, Daniel I. (author)
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Kao, W. H. Linda (author)
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Fox, Caroline S. (author)
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(creator_code:org_t)
- 2012-03-29
- 2012
- English.
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In: PLoS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 8:3, s. e1002584-
- Related links:
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https://uu.diva-port... (primary) (Raw object)
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https://journals.plo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genomewide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A1, CDK12, CASP9, and INO80. Morpholino knockdown of mpped2 and casp9 in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Pattaro, Cristia ...
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Koettgen, Anna
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Teumer, Alexande ...
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Garnaas, Maija
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Boeger, Carsten ...
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Fuchsberger, Chr ...
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show more...
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Olden, Matthias
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Chen, Ming-Huei
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Tin, Adrienne
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Taliun, Daniel
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Li, Man
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Gao, Xiaoyi
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Gorski, Mathias
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Yang, Qiong
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Hundertmark, Cla ...
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Foster, Meredith ...
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O'Seaghdha, Cona ...
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Glazer, Nicole
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Isaacs, Aaron
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Liu, Ching-Ti
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Smith, Albert V.
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O'Connell, Jeffr ...
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Struchalin, Maks ...
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Tanaka, Toshiko
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Li, Guo
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Johnson, Andrew ...
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Gierman, Hinco J ...
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Feitosa, Mary
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Hwang, Shih-Jen
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Atkinson, Elizab ...
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Lohman, Kurt
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Cornelis, Marily ...
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Johansson, Åsa
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Toenjes, Anke
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Dehghan, Abbas
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Chouraki, Vincen ...
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Holliday, Elizab ...
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Sorice, Rossella
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Kutalik, Zoltan
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Lehtimaeki, Terh ...
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Esko, Tonu
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Deshmukh, Harsha ...
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Ulivi, Sheila
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Chu, Audrey Y.
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Murgia, Federico
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Trompet, Stella
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Imboden, Medea
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Kollerits, Barba ...
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Pistis, Giorgio
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Harris, Tamara B ...
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Launer, Lenore J ...
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Aspelund, Thor
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Eiriksdottir, Gu ...
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Mitchell, Braxto ...
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Boerwinkle, Eric
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Schmidt, Helena
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Cavalieri, Margh ...
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Rao, Madhumathi
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Hu, Frank B.
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Demirkan, Ayse
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Oostra, Ben A.
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de Andrade, Mari ...
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Turner, Stephen ...
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Ding, Jingzhong
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Andrews, Jeanett ...
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Freedman, Barry ...
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Koenig, Wolfgang
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Illig, Thomas
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Doering, Angela
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Wichmann, H. -Er ...
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Kolcic, Ivana
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Zemunik, Tatijan ...
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Boban, Mladen
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Minelli, Cosetta
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Wheeler, Heather ...
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Igl, Wilmar
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Zaboli, Ghazal
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Wild, Sarah H.
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Wright, Alan F.
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Campbell, Harry
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Ellinghaus, Davi ...
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Nothlings, Ute
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Jacobs, Gunnar
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Biffar, Reiner
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Endlich, Karlhan ...
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Ernst, Florian
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Homuth, Georg
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Kroemer, Heyo K.
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Nauck, Matthias
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Stracke, Sylvia
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Voelker, Uwe
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Voelzke, Henry
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Kovacs, Peter
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Stumvoll, Michae ...
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Magi, Reedik
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Hofman, Albert
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Uitterlinden, An ...
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Rivadeneira, Fer ...
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Aulchenko, Yurii ...
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Polasek, Ozren
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Hastie, Nick
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Vitart, Veroniqu ...
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Helmer, Catherin ...
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Wang, Jie Jin
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Ruggiero, Daniel ...
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Bergmann, Sven
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Kaehoenen, Mika
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Viikari, Jorma
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Nikopensius, Tii ...
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Province, Michae ...
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Ketkar, Shamika
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Colhoun, Helen
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Doney, Alex
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Robino, Antoniet ...
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Giulianini, Fran ...
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Kraemer, Bernhar ...
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Portas, Laura
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Ford, Ian
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Buckley, Brendan ...
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Adam, Martin
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Thun, Gian-Andri
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Paulweber, Bernh ...
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Haun, Margot
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Sala, Cinzia
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Metzger, Marie
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Mitchell, Paul
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Ciullo, Marina
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Kim, Stuart K.
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Vollenweider, Pe ...
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Raitakari, Olli
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Metspalu, Andres
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Palmer, Colin
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Gasparini, Paolo
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Pirastu, Mario
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Jukema, J. Woute ...
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Probst-Hensch, N ...
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Kronenberg, Flor ...
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Toniolo, Daniela
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Gudnason, Vilmun ...
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Shuldiner, Alan ...
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Coresh, Josef
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Schmidt, Reinhol ...
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Ferrucci, Luigi
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Siscovick, David ...
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van Duijn, Corne ...
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Borecki, Ingrid
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Kardia, Sharon L ...
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Liu, Yongmei
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Curhan, Gary C.
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Rudan, Igor
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Gyllensten, Ulf
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Wilson, James F.
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Franke, Andre
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Pramstaller, Pet ...
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Rettig, Rainer
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Prokopenko, Inga
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Witteman, Jacque ...
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Hayward, Carolin ...
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Ridker, Paul
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Parsa, Afshin
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Bochud, Murielle
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Heid, Iris M.
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Goessling, Wolfr ...
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Chasman, Daniel ...
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Kao, W. H. Linda
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Fox, Caroline S.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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PLoS Genetics
- By the university
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Uppsala University