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Genome-wide associa...
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
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Koettgen, Anna (author)
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Albrecht, Eva (author)
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Teumer, Alexander (author)
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show more...
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Vitart, Veronique (author)
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Krumsiek, Jan (author)
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Hundertmark, Claudia (author)
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Pistis, Giorgio (author)
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Ruggiero, Daniela (author)
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O'Seaghdha, Conall M. (author)
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Haller, Toomas (author)
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Yang, Qiong (author)
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Tanaka, Toshiko (author)
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Johnson, Andrew D. (author)
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Kutalik, Zoltan (author)
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Smith, Albert V. (author)
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Shi, Julia (author)
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Struchalin, Maksim (author)
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Middelberg, Rita P. S. (author)
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Brown, Morris J. (author)
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Gaffo, Angelo L. (author)
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Pirastu, Nicola (author)
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Li, Guo (author)
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Hayward, Caroline (author)
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Zemunik, Tatijana (author)
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Huffman, Jennifer (author)
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Yengo, Loic (author)
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Zhao, Jing Hua (author)
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Demirkan, Ayse (author)
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Feitosa, Mary F. (author)
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Liu, Xuan (author)
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Malerba, Giovanni (author)
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Lopez, Lorna M. (author)
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van der Harst, Pim (author)
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Li, Xinzhong (author)
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Kleber, Marcus E. (author)
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Hicks, Andrew A. (author)
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Nolte, Ilja M. (author)
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- Johansson, Åsa (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för immunologi, genetik och patologi
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Murgia, Federico (author)
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Wild, Sarah H. (author)
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Bakker, Stephan J. L. (author)
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Peden, John F. (author)
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Dehghan, Abbas (author)
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Steri, Maristella (author)
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Tenesa, Albert (author)
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Lagou, Vasiliki (author)
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Salo, Perttu (author)
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Mangino, Massimo (author)
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Rose, Lynda M. (author)
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Lehtimaki, Terho (author)
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Woodward, Owen M. (author)
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Okada, Yukinori (author)
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Tin, Adrienne (author)
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Mueller, Christian (author)
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Oldmeadow, Christopher (author)
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Putku, Margus (author)
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Czamara, Darina (author)
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Kraft, Peter (author)
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Frogheri, Laura (author)
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Thun, Gian Andri (author)
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Grotevendt, Anne (author)
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Gislason, Gauti Kjartan (author)
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Harris, Tamara B. (author)
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Launer, Lenore J. (author)
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McArdle, Patrick (author)
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Shuldiner, Alan R. (author)
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Boerwinkle, Eric (author)
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Coresh, Josef (author)
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Schmidt, Helena (author)
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Schallert, Michael (author)
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Martin, Nicholas G. (author)
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Montgomery, Grant W. (author)
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Kubo, Michiaki (author)
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Nakamura, Yusuke (author)
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Tanaka, Toshihiro (author)
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Munroe, Patricia B. (author)
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Samani, Nilesh J. (author)
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Jacobs, David R., Jr. (author)
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Liu, Kiang (author)
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D'Adamo, Pio (author)
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Ulivi, Sheila (author)
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Rotter, Jerome I. (author)
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Psaty, Bruce M. (author)
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Vollenweider, Peter (author)
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Waeber, Gerard (author)
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Campbell, Susan (author)
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Devuyst, Olivier (author)
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Navarro, Pau (author)
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Kolcic, Ivana (author)
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Hastie, Nicholas (author)
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Balkau, Beverley (author)
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Froguel, Philippe (author)
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Esko, Tonu (author)
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Salumets, Andres (author)
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Khaw, Kay Tee (author)
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Langenberg, Claudia (author)
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Wareham, Nicholas J. (author)
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Isaacs, Aaron (author)
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Kraja, Aldi (author)
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Zhang, Qunyuan (author)
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Wild, Philipp S. (author)
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Scott, Rodney J. (author)
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Holliday, Elizabeth G. (author)
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Org, Elin (author)
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Viigimaa, Margus (author)
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Bandinelli, Stefania (author)
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Metter, Jeffrey E. (author)
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Lupo, Antonio (author)
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Trabetti, Elisabetta (author)
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Sorice, Rossella (author)
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Doering, Angela (author)
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Lattka, Eva (author)
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Strauch, Konstantin (author)
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Theis, Fabian (author)
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Waldenberger, Melanie (author)
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Wichmann, H-Erich (author)
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Davies, Gail (author)
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Gow, Alan J. (author)
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Bruinenberg, Marcel (author)
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Stolk, Ronald P. (author)
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Kooner, Jaspal S. (author)
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Zhang, Weihua (author)
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Winkelmann, Bernhard R. (author)
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Boehm, Bernhard O. (author)
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Lucae, Susanne (author)
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Penninx, Brenda W. (author)
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Smit, Johannes H. (author)
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Curhan, Gary (author)
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Mudgal, Poorva (author)
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Plenge, Robert M. (author)
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Portas, Laura (author)
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Persico, Ivana (author)
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Kirin, Mirna (author)
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Wilson, James F. (author)
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Leach, Irene Mateo (author)
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van Gilst, Wiek H. (author)
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Goel, Anuj (author)
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Ongen, Halit (author)
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Hofman, Albert (author)
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Rivadeneira, Fernando (author)
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Uitterlinden, Andre G. (author)
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Imboden, Medea (author)
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von Eckardstein, Arnold (author)
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Cucca, Francesco (author)
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Nagaraja, Ramaiah (author)
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Piras, Maria Grazia (author)
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Nauck, Matthias (author)
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Schurmann, Claudia (author)
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Budde, Kathrin (author)
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Ernst, Florian (author)
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Farrington, Susan M. (author)
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Theodoratou, Evropi (author)
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Prokopenko, Inga (author)
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Stumvoll, Michael (author)
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Jula, Antti (author)
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Perola, Markus (author)
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Salomaa, Veikko (author)
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Shin, So-Youn (author)
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Spector, Tim D. (author)
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Sala, Cinzia (author)
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Ridker, Paul M. (author)
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Kaehoenen, Mika (author)
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Viikari, Jorma (author)
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Hengstenberg, Christian (author)
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Nelson, Christopher P. (author)
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Meschia, James F. (author)
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Nalls, Michael A. (author)
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Sharma, Pankaj (author)
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Singleton, Andrew B. (author)
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Kamatani, Naoyuki (author)
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Zeller, Tanja (author)
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Burnier, Michel (author)
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Attia, John (author)
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Laan, Maris (author)
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Klopp, Norman (author)
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Hillege, Hans L. (author)
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Kloiber, Stefan (author)
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Choi, Hyon (author)
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Pirastu, Mario (author)
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Tore, Silvia (author)
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Probst-Hensch, Nicole M. (author)
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Voelzke, Henry (author)
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Gudnason, Vilmundur (author)
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Parsa, Afshin (author)
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Schmidt, Reinhold (author)
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Whitfield, John B. (author)
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Fornage, Myriam (author)
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Gasparini, Paolo (author)
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Siscovick, David S. (author)
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Polasek, Ozren (author)
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Campbell, Harry (author)
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Rudan, Igor (author)
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Bouatia-Naji, Nabila (author)
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Metspalu, Andres (author)
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Loos, Ruth J. F. (author)
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van Duijn, Cornelia M. (author)
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Borecki, Ingrid B. (author)
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Ferrucci, Luigi (author)
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Gambaro, Giovanni (author)
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Deary, Ian J. (author)
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Wolffenbuttel, Bruce H. R. (author)
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Chambers, John C. (author)
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Maerz, Winfried (author)
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Pramstaller, Peter P. (author)
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Snieder, Harold (author)
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- Gyllensten, Ulf (author)
- Uppsala universitet,Genomik
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Wright, Alan F. (author)
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Navis, Gerjan (author)
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Watkins, Hugh (author)
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Witteman, Jacqueline C. M. (author)
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Sanna, Serena (author)
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Schipf, Sabine (author)
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Dunlop, Malcolm G. (author)
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Toenjes, Anke (author)
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Ripatti, Samuli (author)
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Soranzo, Nicole (author)
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Toniolo, Daniela (author)
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Chasman, Daniel I. (author)
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Raitakari, Olli (author)
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Kao, W. H. Linda (author)
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Ciullo, Marina (author)
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Fox, Caroline S. (author)
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Caulfield, Mark (author)
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Bochud, Murielle (author)
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Gieger, Christian (author)
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(creator_code:org_t)
- 2012-12-23
- 2013
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:2, s. 145-154
- Related links:
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https://serval.unil....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SEMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout.
Publication and Content Type
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Koettgen, Anna
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Albrecht, Eva
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Teumer, Alexande ...
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Vitart, Veroniqu ...
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Krumsiek, Jan
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Hundertmark, Cla ...
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show more...
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Pistis, Giorgio
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Ruggiero, Daniel ...
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O'Seaghdha, Cona ...
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Haller, Toomas
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Yang, Qiong
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Tanaka, Toshiko
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Johnson, Andrew ...
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Kutalik, Zoltan
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Smith, Albert V.
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Shi, Julia
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Struchalin, Maks ...
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Middelberg, Rita ...
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Brown, Morris J.
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Gaffo, Angelo L.
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Pirastu, Nicola
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Li, Guo
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Hayward, Carolin ...
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Zemunik, Tatijan ...
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Huffman, Jennife ...
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Yengo, Loic
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Zhao, Jing Hua
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Demirkan, Ayse
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Feitosa, Mary F.
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Liu, Xuan
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Malerba, Giovann ...
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Lopez, Lorna M.
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van der Harst, P ...
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Li, Xinzhong
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Kleber, Marcus E ...
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Hicks, Andrew A.
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Nolte, Ilja M.
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Johansson, Åsa
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Murgia, Federico
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Wild, Sarah H.
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Bakker, Stephan ...
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Peden, John F.
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Dehghan, Abbas
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Steri, Maristell ...
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Tenesa, Albert
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Lagou, Vasiliki
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Salo, Perttu
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Mangino, Massimo
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Rose, Lynda M.
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Lehtimaki, Terho
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Woodward, Owen M ...
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Okada, Yukinori
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Tin, Adrienne
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Mueller, Christi ...
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Oldmeadow, Chris ...
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Putku, Margus
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Czamara, Darina
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Kraft, Peter
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Frogheri, Laura
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Thun, Gian Andri
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Grotevendt, Anne
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Gislason, Gauti ...
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Harris, Tamara B ...
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Launer, Lenore J ...
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McArdle, Patrick
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Shuldiner, Alan ...
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Boerwinkle, Eric
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Coresh, Josef
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Schmidt, Helena
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Schallert, Micha ...
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Martin, Nicholas ...
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Montgomery, Gran ...
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Kubo, Michiaki
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Nakamura, Yusuke
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Tanaka, Toshihir ...
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Munroe, Patricia ...
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Samani, Nilesh J ...
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Jacobs, David R. ...
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Liu, Kiang
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D'Adamo, Pio
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Ulivi, Sheila
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Rotter, Jerome I ...
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Psaty, Bruce M.
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Vollenweider, Pe ...
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Waeber, Gerard
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Campbell, Susan
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Devuyst, Olivier
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Navarro, Pau
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Kolcic, Ivana
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Hastie, Nicholas
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Balkau, Beverley
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Froguel, Philipp ...
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Esko, Tonu
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Salumets, Andres
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Khaw, Kay Tee
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Langenberg, Clau ...
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Wareham, Nichola ...
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Isaacs, Aaron
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Kraja, Aldi
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Zhang, Qunyuan
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Wild, Philipp S.
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Scott, Rodney J.
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Holliday, Elizab ...
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Org, Elin
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Viigimaa, Margus
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Bandinelli, Stef ...
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Metter, Jeffrey ...
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Lupo, Antonio
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Trabetti, Elisab ...
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Sorice, Rossella
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Doering, Angela
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Lattka, Eva
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Strauch, Konstan ...
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Theis, Fabian
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Waldenberger, Me ...
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Wichmann, H-Eric ...
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Davies, Gail
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Gow, Alan J.
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Bruinenberg, Mar ...
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Stolk, Ronald P.
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Kooner, Jaspal S ...
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Zhang, Weihua
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Winkelmann, Bern ...
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Boehm, Bernhard ...
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Lucae, Susanne
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Penninx, Brenda ...
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Smit, Johannes H ...
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Curhan, Gary
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Mudgal, Poorva
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Plenge, Robert M ...
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Portas, Laura
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Persico, Ivana
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Kirin, Mirna
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Wilson, James F.
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Leach, Irene Mat ...
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van Gilst, Wiek ...
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Goel, Anuj
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Ongen, Halit
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Hofman, Albert
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Rivadeneira, Fer ...
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Uitterlinden, An ...
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Imboden, Medea
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von Eckardstein, ...
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Cucca, Francesco
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Nagaraja, Ramaia ...
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Piras, Maria Gra ...
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Nauck, Matthias
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Schurmann, Claud ...
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Budde, Kathrin
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Ernst, Florian
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Farrington, Susa ...
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Theodoratou, Evr ...
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Prokopenko, Inga
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Stumvoll, Michae ...
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Jula, Antti
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Perola, Markus
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Salomaa, Veikko
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Shin, So-Youn
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Spector, Tim D.
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Sala, Cinzia
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Ridker, Paul M.
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Kaehoenen, Mika
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Viikari, Jorma
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Hengstenberg, Ch ...
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Nelson, Christop ...
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Meschia, James F ...
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Nalls, Michael A ...
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Sharma, Pankaj
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Singleton, Andre ...
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Kamatani, Naoyuk ...
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Zeller, Tanja
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Burnier, Michel
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Attia, John
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Laan, Maris
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Klopp, Norman
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Hillege, Hans L.
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Kloiber, Stefan
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Choi, Hyon
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Pirastu, Mario
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Tore, Silvia
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Probst-Hensch, N ...
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Voelzke, Henry
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Gudnason, Vilmun ...
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Parsa, Afshin
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Schmidt, Reinhol ...
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Whitfield, John ...
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Fornage, Myriam
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Gasparini, Paolo
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Siscovick, David ...
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Polasek, Ozren
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Campbell, Harry
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Rudan, Igor
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Bouatia-Naji, Na ...
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Metspalu, Andres
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Loos, Ruth J. F.
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van Duijn, Corne ...
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Borecki, Ingrid ...
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Ferrucci, Luigi
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Gambaro, Giovann ...
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Deary, Ian J.
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Wolffenbuttel, B ...
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Chambers, John C ...
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Maerz, Winfried
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Pramstaller, Pet ...
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Snieder, Harold
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Gyllensten, Ulf
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Wright, Alan F.
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Navis, Gerjan
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Watkins, Hugh
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Witteman, Jacque ...
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Sanna, Serena
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Schipf, Sabine
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Dunlop, Malcolm ...
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Toenjes, Anke
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Ripatti, Samuli
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Soranzo, Nicole
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Toniolo, Daniela
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Chasman, Daniel ...
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Raitakari, Olli
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Kao, W. H. Linda
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Ciullo, Marina
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Fox, Caroline S.
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Caulfield, Mark
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Bochud, Murielle
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Gieger, Christia ...
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- Articles in the publication
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Nature Genetics
- By the university
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Uppsala University