Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function

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Pattaro, Cristian (author)

Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function

Article/chapterEnglish2012

Publisher, publication year, extent ...

2012-03-29
Public Library of Science (PLoS),2012
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-174593
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-174593URI
https://doi.org/10.1371/journal.pgen.1002584DOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genomewide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A1, CDK12, CASP9, and INO80. Morpholino knockdown of mpped2 and casp9 in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD.

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Koettgen, Anna (author)
Teumer, Alexander (author)
Garnaas, Maija (author)
Boeger, Carsten A. (author)
Fuchsberger, Christian (author)
Olden, Matthias (author)
Chen, Ming-Huei (author)
Tin, Adrienne (author)
Taliun, Daniel (author)
Li, Man (author)
Gao, Xiaoyi (author)
Gorski, Mathias (author)
Yang, Qiong (author)
Hundertmark, Claudia (author)
Foster, Meredith C. (author)
O'Seaghdha, Conall M. (author)
Glazer, Nicole (author)
Isaacs, Aaron (author)
Liu, Ching-Ti (author)
Smith, Albert V. (author)
O'Connell, Jeffrey R. (author)
Struchalin, Maksim (author)
Tanaka, Toshiko (author)
Li, Guo (author)
Johnson, Andrew D. (author)
Gierman, Hinco J. (author)
Feitosa, Mary (author)
Hwang, Shih-Jen (author)
Atkinson, Elizabeth J. (author)
Lohman, Kurt (author)
Cornelis, Marilyn C. (author)
Johansson, ÅsaUppsala universitet,Genomik,Gyllensten(Swepub:uu)asjoh108 (author)
Toenjes, Anke (author)
Dehghan, Abbas (author)
Chouraki, Vincent (author)
Holliday, Elizabeth G. (author)
Sorice, Rossella (author)
Kutalik, Zoltan (author)
Lehtimaeki, Terho (author)
Esko, Tonu (author)
Deshmukh, Harshal (author)
Ulivi, Sheila (author)
Chu, Audrey Y. (author)
Murgia, Federico (author)
Trompet, Stella (author)
Imboden, Medea (author)
Kollerits, Barbara (author)
Pistis, Giorgio (author)
Harris, Tamara B. (author)
Launer, Lenore J. (author)
Aspelund, Thor (author)
Eiriksdottir, Gudny (author)
Mitchell, Braxton D. (author)
Boerwinkle, Eric (author)
Schmidt, Helena (author)
Cavalieri, Margherita (author)
Rao, Madhumathi (author)
Hu, Frank B. (author)
Demirkan, Ayse (author)
Oostra, Ben A. (author)
de Andrade, Mariza (author)
Turner, Stephen T. (author)
Ding, Jingzhong (author)
Andrews, Jeanette S. (author)
Freedman, Barry I. (author)
Koenig, Wolfgang (author)
Illig, Thomas (author)
Doering, Angela (author)
Wichmann, H. -Erich (author)
Kolcic, Ivana (author)
Zemunik, Tatijana (author)
Boban, Mladen (author)
Minelli, Cosetta (author)
Wheeler, Heather E. (author)
Igl, WilmarUppsala universitet,Institutionen för immunologi, genetik och patologi (author)
Zaboli, GhazalUppsala universitet,Institutionen för immunologi, genetik och patologi (author)
Wild, Sarah H. (author)
Wright, Alan F. (author)
Campbell, Harry (author)
Ellinghaus, David (author)
Nothlings, Ute (author)
Jacobs, Gunnar (author)
Biffar, Reiner (author)
Endlich, Karlhans (author)
Ernst, Florian (author)
Homuth, Georg (author)
Kroemer, Heyo K. (author)
Nauck, Matthias (author)
Stracke, Sylvia (author)
Voelker, Uwe (author)
Voelzke, Henry (author)
Kovacs, Peter (author)
Stumvoll, Michael (author)
Magi, Reedik (author)
Hofman, Albert (author)
Uitterlinden, Andre G. (author)
Rivadeneira, Fernando (author)
Aulchenko, Yurii S. (author)
Polasek, Ozren (author)
Hastie, Nick (author)
Vitart, Veronique (author)
Helmer, Catherine (author)
Wang, Jie Jin (author)
Ruggiero, Daniela (author)
Bergmann, Sven (author)
Kaehoenen, Mika (author)
Viikari, Jorma (author)
Nikopensius, Tiit (author)
Province, Michael (author)
Ketkar, Shamika (author)
Colhoun, Helen (author)
Doney, Alex (author)
Robino, Antonietta (author)
Giulianini, Franco (author)
Kraemer, Bernhard K. (author)
Portas, Laura (author)
Ford, Ian (author)
Buckley, Brendan M. (author)
Adam, Martin (author)
Thun, Gian-Andri (author)
Paulweber, Bernhard (author)
Haun, Margot (author)
Sala, Cinzia (author)
Metzger, Marie (author)
Mitchell, Paul (author)
Ciullo, Marina (author)
Kim, Stuart K. (author)
Vollenweider, Peter (author)
Raitakari, Olli (author)
Metspalu, Andres (author)
Palmer, Colin (author)
Gasparini, Paolo (author)
Pirastu, Mario (author)
Jukema, J. Wouter (author)
Probst-Hensch, Nicole M. (author)
Kronenberg, Florian (author)
Toniolo, Daniela (author)
Gudnason, Vilmundur (author)
Shuldiner, Alan R. (author)
Coresh, Josef (author)
Schmidt, Reinhold (author)
Ferrucci, Luigi (author)
Siscovick, David S. (author)
van Duijn, Cornelia M. (author)
Borecki, Ingrid (author)
Kardia, Sharon L. R. (author)
Liu, Yongmei (author)
Curhan, Gary C. (author)
Rudan, Igor (author)
Gyllensten, UlfUppsala universitet,Genomik,Gyllensten(Swepub:uu)ulfgyll (author)
Wilson, James F. (author)
Franke, Andre (author)
Pramstaller, Peter P. (author)
Rettig, Rainer (author)
Prokopenko, Inga (author)
Witteman, Jacqueline C. M. (author)
Hayward, Caroline (author)
Ridker, Paul (author)
Parsa, Afshin (author)
Bochud, Murielle (author)
Heid, Iris M. (author)
Goessling, Wolfram (author)
Chasman, Daniel I. (author)
Kao, W. H. Linda (author)
Fox, Caroline S. (author)
Uppsala universitetGenomik (creator_code:org_t)

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In:PLoS Genetics: Public Library of Science (PLoS)8:3, s. e1002584-1553-73901553-7404

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By the author/editor: Pattaro, Cristia ...; Koettgen, Anna; Teumer, Alexande ...; Garnaas, Maija; Boeger, Carsten ...; Fuchsberger, Chr ...; show more...; Olden, Matthias; Chen, Ming-Huei; Tin, Adrienne; Taliun, Daniel; Li, Man; Gao, Xiaoyi; Gorski, Mathias; Yang, Qiong; Hundertmark, Cla ...; Foster, Meredith ...; O'Seaghdha, Cona ...; Glazer, Nicole; Isaacs, Aaron; Liu, Ching-Ti; Smith, Albert V.; O'Connell, Jeffr ...; Struchalin, Maks ...; Tanaka, Toshiko; Li, Guo; Johnson, Andrew ...; Gierman, Hinco J ...; Feitosa, Mary; Hwang, Shih-Jen; Atkinson, Elizab ...; Lohman, Kurt; Cornelis, Marily ...; Johansson, Åsa; Toenjes, Anke; Dehghan, Abbas; Chouraki, Vincen ...; Holliday, Elizab ...; Sorice, Rossella; Kutalik, Zoltan; Lehtimaeki, Terh ...; Esko, Tonu; Deshmukh, Harsha ...; Ulivi, Sheila; Chu, Audrey Y.; Murgia, Federico; Trompet, Stella; Imboden, Medea; Kollerits, Barba ...; Pistis, Giorgio; Harris, Tamara B ...; Launer, Lenore J ...; Aspelund, Thor; Eiriksdottir, Gu ...; Mitchell, Braxto ...; Boerwinkle, Eric; Schmidt, Helena; Cavalieri, Margh ...; Rao, Madhumathi; Hu, Frank B.; Demirkan, Ayse; Oostra, Ben A.; de Andrade, Mari ...; Turner, Stephen ...; Ding, Jingzhong; Andrews, Jeanett ...; Freedman, Barry ...; Koenig, Wolfgang; Illig, Thomas; Doering, Angela; Wichmann, H. -Er ...; Kolcic, Ivana; Zemunik, Tatijan ...; Boban, Mladen; Minelli, Cosetta; Wheeler, Heather ...; Igl, Wilmar; Zaboli, Ghazal; Wild, Sarah H.; Wright, Alan F.; Campbell, Harry; Ellinghaus, Davi ...; Nothlings, Ute; Jacobs, Gunnar; Biffar, Reiner; Endlich, Karlhan ...; Ernst, Florian; Homuth, Georg; Kroemer, Heyo K.; Nauck, Matthias; Stracke, Sylvia; Voelker, Uwe; Voelzke, Henry; Kovacs, Peter; Stumvoll, Michae ...; Magi, Reedik; Hofman, Albert; Uitterlinden, An ...; Rivadeneira, Fer ...; Aulchenko, Yurii ...; Polasek, Ozren; Hastie, Nick; Vitart, Veroniqu ...; Helmer, Catherin ...; Wang, Jie Jin; Ruggiero, Daniel ...; Bergmann, Sven; Kaehoenen, Mika; Viikari, Jorma; Nikopensius, Tii ...; Province, Michae ...; Ketkar, Shamika; Colhoun, Helen; Doney, Alex; Robino, Antoniet ...; Giulianini, Fran ...; Kraemer, Bernhar ...; Portas, Laura; Ford, Ian; Buckley, Brendan ...; Adam, Martin; Thun, Gian-Andri; Paulweber, Bernh ...; Haun, Margot; Sala, Cinzia; Metzger, Marie; Mitchell, Paul; Ciullo, Marina; Kim, Stuart K.; Vollenweider, Pe ...; Raitakari, Olli; Metspalu, Andres; Palmer, Colin; Gasparini, Paolo; Pirastu, Mario; Jukema, J. Woute ...; Probst-Hensch, N ...; Kronenberg, Flor ...; Toniolo, Daniela; Gudnason, Vilmun ...; Shuldiner, Alan ...; Coresh, Josef; Schmidt, Reinhol ...; Ferrucci, Luigi; Siscovick, David ...; van Duijn, Corne ...; Borecki, Ingrid; Kardia, Sharon L ...; Liu, Yongmei; Curhan, Gary C.; Rudan, Igor; Gyllensten, Ulf; Wilson, James F.; Franke, Andre; Pramstaller, Pet ...; Rettig, Rainer; Prokopenko, Inga; Witteman, Jacque ...; Hayward, Carolin ...; Ridker, Paul; Parsa, Afshin; Bochud, Murielle; Heid, Iris M.; Goessling, Wolfr ...; Chasman, Daniel ...; Kao, W. H. Linda; Fox, Caroline S.; show less...

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