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Risk factors for ca...
Risk factors for cardiovascular disease are increased in young adults treated with stem cell transplantation during childhood
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- Frisk, Per (author)
- Uppsala universitet,Pediatrik,Barnonkologisk forskning/Ljungman
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- Arvidson, Johan (author)
- Uppsala universitet,Pediatrik,Barnonkologisk forskning/Ljungman
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- Larsson, Marita (author)
- Uppsala universitet,Obstetrik & gynekologi,Gynekologisk endokrinologi/Naessén
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- Naessén, Tord (author)
- Uppsala universitet,Obstetrik & gynekologi,Gynekologisk endokrinologi/Naessén
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(creator_code:org_t)
- 2012-04-04
- 2012
- English.
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In: Pediatric Transplantation. - : Wiley. - 1397-3142 .- 1399-3046. ; 16:4, s. 385-391
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- We measured risk factors for CVD in 18 patients at a median of 18.2 yr after SCT and in sex and age-matched controls. Three patients (17%), but none of the controls, met the criteria for the MetS (p = 0.25). In the patients, we found higher levels of triglycerides (0.94 vs. 0.62 mm, p = 0.019), total cholesterol (5.1 vs. 4.0 mm, p = 0.017), LDL (3.4 vs. 2.6 mm, p = 0.019), apolipoprotein B (1.04 vs. 0.74 g/L, p = 0.004), apolipoprotein B/A1 ratio (0.7 vs. 0.5, p = 0.026), and lower levels of adiponectin (4.9 vs. 7.5 mg/L, p = 0.008) than in the controls. The patients had a lower GHmax (9 vs. 20.7 mU/L, p = 0.002). GHmax was significantly correlated inversely with triglycerides (r = -0.64, p = 0.008), total cholesterol (r = -0.61, p = 0.011), apolipoprotein B (r = -0.60, p = 0.014), and apolipoprotein B/A1 ratio (r = -0.66, p = 0.005). We recorded a significantly thicker carotid intima layer among the patients than among matched controls (0.15 vs. 0.13 mm, p = 0.034). The level of adiponectin correlated inversely with carotid intima thickness (r = -0.55, p = 0.023). After SCT in childhood, long-term survivors may be at risk of developing premature CVD.
Keyword
- stem cell transplantation
- cardiovascular disease
- metabolic syndrome
- intima and media thickness
- adiponectin
Publication and Content Type
- ref (subject category)
- art (subject category)
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