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Two Loci on Chromos...
Two Loci on Chromosome 5 Are Associated with Serum IgE Levels in Labrador Retrievers
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Owczarek-Lipska, Marta (author)
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Lauber, Béatrice (author)
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Molitor, Vivianne (author)
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Meury, Sabrina (author)
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- Kierczak, Marcin (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences
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- Tengvall, Katarina (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences
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- Webster, Matthew T. (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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Jagannathan, Vidhya (author)
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Schlotter, Yvette (author)
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Willemse, Ton (author)
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Hendricks, Anke (author)
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- Bergvall, Kerstin (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences
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- Hedhammar, Åke (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences
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- Andersson, Göran (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics
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- Lindblad-Toh, Kerstin (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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Favrot, Claude (author)
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Roosje, Petra (author)
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Marti, Eliane (author)
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Leeb, Tosso (author)
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(creator_code:org_t)
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- 2012-06-15
- 2012
- English.
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 7:6, s. e39176-
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https://journals.plo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Crosslinking of immunoglobulin E antibodies (IgE) bound at the surface of mast cells and subsequent mediator release is considered the most important trigger for allergic reactions. Therefore, the genetic control of IgE levels is studied in the context of allergic diseases, such as asthma, atopic rhinitis, or atopic dermatitis (AD). We performed genome-wide association studies in 161 Labrador Retrievers with regard to total and allergen-specific immunoglobulin E (IgE) levels. We identified a genome-wide significant association on CFA 5 with the antigen-specific IgE responsiveness to Acarus siro. We detected a second genome-wide significant association with respect to the antigen-specific IgE responsiveness to Tyrophagus putrescentiae at a different locus on chromosome 5. A. siro and T. putrescentiae both belong to the family Acaridae and represent so-called storage or forage mites. These forage mites are discussed as major allergen sources in canine AD. No obvious candidate gene for the regulation of IgE levels is located under the two association signals. Therefore our studies offer a chance of identifying a novel mechanism controlling the host's IgE response.
Subject headings
- LANTBRUKSVETENSKAPER -- Bioteknologi med applikationer på växter och djur -- Genetik och förädling inom lantbruksvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agricultural Biotechnology -- Genetics and Breeding in Agricultural Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Owczarek-Lipska, ...
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Lauber, Béatrice
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Molitor, Viviann ...
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Meury, Sabrina
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Kierczak, Marcin
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Tengvall, Katari ...
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show more...
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Webster, Matthew ...
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Jagannathan, Vid ...
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Schlotter, Yvett ...
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Willemse, Ton
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Hendricks, Anke
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Bergvall, Kersti ...
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Hedhammar, Åke
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Andersson, Göran
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Lindblad-Toh, Ke ...
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Favrot, Claude
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Roosje, Petra
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Marti, Eliane
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Leeb, Tosso
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- About the subject
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Agricultural Bio ...
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and Genetics and Bre ...
- Articles in the publication
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PLOS ONE
- By the university
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Uppsala University
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Swedish University of Agricultural Sciences