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Baseline NT-proBNP ...
Baseline NT-proBNP and biomarkers of inflammation and necrosis in patients with ST-segment elevation myocardial infarction : insights from the APEX-AMI trial
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van Diepen, Sean (author)
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Roe, Matthew T. (author)
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Lopes, Renato D. (author)
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Stebbins, Amanda (author)
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- James, Stefan (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),kardiologi
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Newby, L. Kristin (author)
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Moliterno, David J. (author)
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Neumann, Franz-Josef (author)
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Ezekowitz, Justin A. (author)
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Mahaffey, Kenneth W. (author)
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Hochman, Judith S. (author)
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Hamm, Christian W. (author)
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Armstrong, Paul W. (author)
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Theroux, Pierre (author)
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Granger, Christopher B. (author)
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(creator_code:org_t)
- 2012-02-04
- 2012
- English.
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In: Journal of Thrombosis and Thrombolysis. - : Springer Science and Business Media LLC. - 0929-5305 .- 1573-742X. ; 34:1, s. 106-113
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Coronary plaque rupture is associated with a systemic inflammatory response. The relationship between baseline N-terminal pro B-type natriuretic peptide (NT-proBNP), a prognostic marker in patients with acute coronary syndromes, and systemic inflammatory mediators in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI) is not well described. Of 5,745 STEMI patients treated with primary PCI in the APEX-AMI trial, we evaluated the relationship between baseline NT-proBNP levels and baseline levels of inflammatory markers and markers of myonecrosis in a subset of 772 who were enrolled in a biomarker substudy. Spearman correlations (r (s)) were calculated between baseline NT-proBNP levels and a panel of ten systemic inflammatory biomarkers. Interleukin (IL)-6, a pro-inflammatory cytokine, was significantly positively correlated with NT-proBNP (r (s) = 0.317, P < 0.001). In a sensitivity analysis excluding all heart failure patients, the correlation between baseline IL-6 and NT-proBNP remained significant (n = 651, r (s) = 0.296, P < 0.001). A positive association was also observed with high sensitivity C-reactive protein (r (s) = 0.377, P < 0.001) and there was a weak negative correlation with the anti-inflammatory cytokine IL-10 (r (s) = -0.109, P = 0.003). No other significant correlations were observed among the other testes inflammatory cytokines and chemokines. In STEMI patients undergoing primary PCI, the pro-inflammatory cytokine IL-6 was modestly correlated with baseline NT-proBNP levels. This relationship remained significant in patients without heart failure. This finding is consistent with pre-clinical and clinical research suggesting that systemic inflammation may influence NT-proBNP expression independently of myocardial stretch.
Keyword
- N-terminal pro-brain natriuretic peptide
- Interleukin-6
- Interleukin-10
- C-reactive protein
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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van Diepen, Sean
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Roe, Matthew T.
-
Lopes, Renato D.
-
Stebbins, Amanda
-
James, Stefan
-
Newby, L. Kristi ...
-
show more...
-
Moliterno, David ...
-
Neumann, Franz-J ...
-
Ezekowitz, Justi ...
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Mahaffey, Kennet ...
-
Hochman, Judith ...
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Hamm, Christian ...
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Armstrong, Paul ...
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Theroux, Pierre
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Granger, Christo ...
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show less...
- Articles in the publication
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Journal of Throm ...
- By the university
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Uppsala University