SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Winding Robert)
 

Search: WFRF:(Winding Robert) > Hydroxyethyl Starch...

  • Perner, Anders (author)

Hydroxyethyl Starch 130/0.4 versus Ringer's Acetate in Severe Sepsis

  • Article/chapterEnglish2012

Publisher, publication year, extent ...

  • 2012
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-178080
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-178080URI
  • https://doi.org/10.1056/NEJMoa1204242DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND Hydroxyethyl starch (HES) 130/0.4 is widely used for fluid resuscitation in intensive care units (ICUs), but its safety and efficacy have not been established in patients with severe sepsis. METHODS In this multicenter, parallel-group, blinded trial, we randomly assigned patients with severe sepsis to fluid resuscitation in the ICU with either 6% HES 130/0.4 or Ringer's acetate at a dose of up to 33 ml per kilogram of ideal body weight per day. The primary outcome measure was either death or end-stage kidney failure (dependence on dialysis) at 90 days after randomization. RESULTS Of the 804 patients who underwent randomization, 798 were included in the modified intention-to-treat population. The two intervention groups had similar baseline characteristics. At 90 days after randomization, 201 of 398 patients (51%) assigned to HES 130/0.4 had died, as compared with 172 of 400 patients (43%) assigned to Ringer's acetate (relative risk, 1.17; 95% confidence interval [CI], 1.01 to 1.36; P=0.03); 1 patient in each group had end-stage kidney failure. In the 90-day period, 87 patients (22%) assigned to HES 130/0.4 were treated with renal-replacement therapy versus 65 patients (16%) assigned to Ringer's acetate (relative risk, 1.35; 95% CI, 1.01 to 1.80; P=0.04), and 38 patients (10%) and 25 patients (6%), respectively, had severe bleeding (relative risk, 1.52; 95% CI, 0.94 to 2.48; P=0.09). The results were supported by multivariate analyses, with adjustment for known risk factors for death or acute kidney injury at baseline. CONCLUSIONS Patients with severe sepsis assigned to fluid resuscitation with HES 130/0.4 had an increased risk of death at day 90 and were more likely to require renal-replacement therapy, as compared with those receiving Ringer's acetate. 

Added entries (persons, corporate bodies, meetings, titles ...)

  • Haase, Nicolai (author)
  • Guttormsen, Anne B. (author)
  • Tenhunen, JyrkiUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)jyrte348 (author)
  • Klemenzson, Gudmundur (author)
  • Åneman, Anders (author)
  • Madsen, Kristian R. (author)
  • Moller, Morten H. (author)
  • Elkjaer, Jeanie M. (author)
  • Poulsen, Lone M. (author)
  • Bendtsen, Asger (author)
  • Winding, Robert (author)
  • Steensen, Morten (author)
  • Berezowicz, Pawel (author)
  • Søe-Jensen, Peter (author)
  • Bestle, Morten (author)
  • Strand, Kristian (author)
  • Wiis, Jørgen (author)
  • White, Jonathan O. (author)
  • Thornberg, Klaus J. (author)
  • Quist, Lars (author)
  • Nielsen, Jonas (author)
  • Andersen, Lasse H. (author)
  • Holst, Lars B. (author)
  • Thormar, Katrin (author)
  • Kjaeldgaard, Anne-Lene (author)
  • Fabritius, Maria L. (author)
  • Mondrup, Frederik (author)
  • Pott, Frank C. (author)
  • Møller, Thea P. (author)
  • Winkel, Per (author)
  • Wetterslev, Jørn (author)
  • Uppsala universitetAnestesiologi och intensivvård (creator_code:org_t)

Related titles

  • In:New England Journal of Medicine367:2, s. 124-1340028-47931533-4406

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view