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  • Gulseth, Hanne L. (author)

Serum Vitamin D Concentration Does Not Predict Insulin Action or Secretion in European Subjects With the Metabolic Syndrome

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • 2010-01-12
  • American Diabetes Association,2010
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-136974
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-136974URI
  • https://doi.org/10.2337/dc09-1692DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • OBJECTIVE To investigate the relation between serum concentration of 25-hydroxyvitamin D [25(OH)D] and insulin action and secretion. RESEARCH DESIGN AND METHODS In a cross-sectional study of 446 Pan-European subjects with the metabolic syndrome, insulin action and secretion were assessed by homeostasis model assessment (HOMA) indexes and intravenous glucose tolerance test to calculate acute insulin response, insulin sensitivity, and disposition index. Serum 25(OH)D was measured by high-performance liquid chromatography/mass spectrometry. RESULTS - The 25(OH)D-3 concentration was 57.1 +/- 26.0 nmol/l (mean +/- SD), and only 20% of the subjects had 25(OH)D-3 levels >= 75 nmol/l. In multiple linear analyses, 25(OH)D-3 concentrations were not associated with parameters of insulin action or secretion after adjustment for BMI and other covariates. CONCLUSIONS In a large sample of subjects with the metabolic syndrome, serum concentrations of 25(OH)D-3 did not predict insulin action or secretion. Clear evidence that D vitamin status directly influences insulin secretion or action is still lacking.

Subject headings and genre

  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Gjelstad, Ingrid M. F. (author)
  • Tierney, Audrey C. (author)
  • Lovegrove, Julie A. (author)
  • Defoort, Catherine (author)
  • Blaak, Ellen E. (author)
  • Lopez-Miranda, Jose (author)
  • Kiec-Wilk, Beata (author)
  • Risérus, UlfUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)ulfriser (author)
  • Roche, Helen M. (author)
  • Drevon, Christian A. (author)
  • Birkeland, Kare I. (author)
  • Uppsala universitetKlinisk nutrition och metabolism (creator_code:org_t)

Related titles

  • In:Diabetes Care: American Diabetes Association33:4, s. 923-9250149-59921935-5548

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